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首页> 外文期刊>Frontiers in Medicine >The Translational Medicine Professional: A Bridge Between Bench and Bedside?
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The Translational Medicine Professional: A Bridge Between Bench and Bedside?

机译：转化医学专业人士：在长凳和床头架上架起一座桥梁？

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Translational medicine (TM) can be defined as the interdisciplinary application of biomedical research for the improvement of health of patients and society. The focus of TM has so far been largely on the bench-to-bedside rather than bedside-community transition of research. Several “Valleys of Death” in this process have been described, identifying transitional failures that may halt or impede the pathway, which would otherwise lead to the development of medicines, technologies, and/or evidence based practice guidelines. In order to help bridge these gaps, increasing patient-orientated research at each stage could improve the success of projects and increase societal impact. Increasing the accessibility and involvement of patients in TM outside of traditional research centers, such as universities and teaching hospitals, is one crucial pre-requisite. For example, where clinical research units with active links to local universities have been set-up, research participation can be increased. Such non-traditional research centers (NRTCs) might include primary or secondary care services, or even social care institutions. TM professionals (TMPs) from multi-disciplinary backgrounds, with work experience in university or research centers and with experience of TM, could play a vital role in this organizational change. TMPs in NTRCs are well placed to collaborate with local universities, larger research centers and commercial research and development organizations. Exchanging information could benefit all shareholders involved. TMPs can also stimulate the education and innovative thinking that is required for TM to achieve its full societal impact. We discuss the scope of a potential role for TMPs in NTRCs, as well as the possible barriers and difficulties they might face, along with measures that could widen the accessibility of TM outside of the traditional setting.
机译：转化医学（TM）可以定义为生物医学研究的跨学科应用，可以改善患者和社会的健康状况。迄今为止，TM的重点主要集中在研究的从台到床，而不是从床头到社区的转变。已经描述了此过程中的几个“死亡谷”，确定了可能会终止或阻碍该途径的过渡性失败，否则将导致药物，技术和/或循证医学实践指南的发展。为了弥合这些差距，在每个阶段增加以患者为中心的研究可以提高项目的成功率，并增加社会影响力。在传统研究中心（例如大学和教学医院）之外增加TM患者的可及性和参与度是一项关键的先决条件。例如，在建立了与当地大学有积极联系的临床研究单位的情况下，可以增加研究的参与度。这样的非传统研究中心（NRTC）可能包括初级或二级护理服务，甚至社会护理机构。来自多学科背景的TM专业人员（TMP），具有在大学或研究中心的工作经验以及具有TM的经验，可以在这种组织变革中发挥至关重要的作用。 NTRC中的TMP非常适合与当地大学，大型研究中心和商业研究与开发组织合作。交流信息可以使所有相关股东受益。 TMP还可以激发TM发挥其完整的社会影响所需的教育和创新思维。我们讨论了NTRC中TMP潜在作用的范围，以及它们可能面临的障碍和困难，以及可以扩大传统环境之外TM的可及性的措施。

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