Graphene electrochemical sensors for the detection of S 29:1-(2-chloro-2-(4-chlorophenyl)ethyl)-N-(4-fluorobenzyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine: an anticancer drug

Federica Valentini; Simonetta Antonaroli; Giulia Iovenitti; Maurizio Botta; Maurizio Talamo

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Graphene electrochemical sensors for the detection of S 29:1-(2-chloro-2-(4-chlorophenyl)ethyl)-N-(4-fluorobenzyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine: an anticancer drug

机译：用于检测S 29：1-（2-氯-2-（4-氯苯基）乙基）-N-（4-氟苄基）-1H-吡唑并[3,4-d]嘧啶-4-胺的石墨烯电化学传感器：抗癌药

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Commentary Graphene (G) and Graphene derivatives (Gds) represent the next generation of smart materials, having exciting features to apply in Medicine field. Especially, several studies [1,2] report about the biocompatibility of graphene and graphene derivatives in several different cell lines. Biocompatibility for G and Gds seems to be related to main aspects, as: the metal-free chemical composition of graphene and the nano sheets shape. Recently, Valentini, et al. [3] report about the in vitro biocompatibility of Graphene Oxide (GO) nanosheets, tested in different human cell lines and compared with that exhibited by Single Wall Carbon Nanotubes (SWCNTs).

机译：评注石墨烯（G）和石墨烯衍生物（Gds）代表了下一代智能材料，具有激动人心的特性，可应用于医学领域。尤其是，一些研究[1,2]报告了石墨烯和石墨烯衍生物在几种不同细胞系中的生物相容性。 G和Gds的生物相容性似乎与主要方面有关，例如：石墨烯的无金属化学组成和纳米片的形状。最近，Valentini等人。 [3]报告了氧化石墨烯（GO）纳米片的体外生物相容性，该纳米片在不同的人类细胞系中进行了测试，并与单壁碳纳米管（SWCNTs）进行了比较。

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《Frontiers in Nanoscience and Nanotechnology》 |2018年第3期|共3页
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Federica Valentini; Simonetta Antonaroli; Giulia Iovenitti; Maurizio Botta; Maurizio Talamo;
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1. GO Nanosheets: Promising Nano Carrier for the S29, 1-(2-Chloro-2-(4-chlorophenyl-ethyl)- N -(4-fluorobenzyl)-1 H -pyrazolo[3,4-d] pyrimidin-4-amine, Therapeutic Agent in Neuroblastoma [J] . Stefania Mardente, Michele Aventaggiato, Emanuela Mari, International Journal of Molecular Sciences . 2020,第17期

机译：Go nanosheets：对S29,1-（2-氯-2-（4-氯苯基乙基） - N - （4-氟苄基）-1h -pyrazolo [3,4-d]嘧啶-4- 4-胺，神经母细胞瘤中的治疗剂
2. From Lead to Drug Candidate: Optimization of 3-(Phenylethyny1)-1H-pyrazolo[3,4-d]pyrimidin-4-amine Derivatives as Agents for the Treatment of Triple Negative Breast Cancer [J] . Zhang Chun-Hui, Chen Kai, Jiao Yan, Journal of Medicinal Chemistry . 2016,第21期

机译：从铅到药物候选者：3-（Phenylethyny1）-1H-吡唑并[3,4-d]嘧啶-4-胺衍生物作为三阴性乳腺癌治疗药物的优化
3. New cannabimimetic indazole derivatives, N-(1-amino-3-methyl-1-oxobutan-2-yl)-1-pentyl-1H-indazole-3-carboxamide (AB-PINACA) and N-(1-amino-3-methyl-1-oxobutan-2-yl)-1-(4-fluorobenzyl)-1H-indazole-3-carboxamide (AB-FUBINACA) identified as designer drugs in illegal products [J] . Nahoko Uchiyama, Satoru Matsuda, Daigo Wakana, Forensic Toxicology . 2013,第1期

机译：新的大麻拟吲唑衍生物N-（1-氨基-3-甲基-1-氧丁烷-2-基）-1-戊基-1H-吲唑-3-羧酰胺（AB-PINACA）和N-（1-氨基-3 -甲基-1-氧代丁烷-2-基）-1-（4-氟苄基）-1H-吲唑-3-羧酰胺（AB-FUBINACA）被确认为非法产品中的设计药物
4. Spectroscopic investigations of the interaction of BSA and DNA with the anticancer drug, N-(6-ferrocenyl-2-naphthoyl) glycine alanine ethyl ester (FNGAEE) [C] . S. R. Rajina, S. G. Praveen, T. S. Xavier, International Conference on Condensed Matter and Applied Physics . 2020

机译：对BSA和DNA与抗癌药物的相互作用的光谱研究，N-（6-二茂茂烯基-2-萘酰）甘氨酸丙氨酸乙酯（FNGAEE）
5. Development of Novel Integrated Microfluidic Electrochemical Point-of-Care Sensors for Pathogen Detection and Continuous Drug Monitoring [D] . Ferguson, Brian Scott 2011

机译：用于病原体检测和连续药物监测的新型集成式微流电化学护理点传感器的开发
6. GO Nanosheets: Promising Nano Carrier for the S29 1-(2-Chloro-2-(4-chlorophenyl-ethyl)- [O] . Stefania Mardente, Michele Aventaggiato, Emanuela Mari, 2020

机译：Go Nanosheets：对S291-（2-氯-2-（4-氯苯基 - 乙基）的有前途的纳米载体 -
7. Highly Sensitive Electrochemical Sensor for Anticancer Drug by a Zirconia Nanoparticle-Decorated Reduced Graphene Oxide Nanocomposite [O] . Manthrapudi Venu, Sada Venkateswarlu, Yenugu Veera Manohara Reddy, 2018

机译：抗癌药物高敏感的电化学传感器通过氧化锆纳米粒子装饰的石墨烯氧化物纳米复合材料

Graphene electrochemical sensors for the detection of S 29:1-(2-chloro-2-(4-chlorophenyl)ethyl)-N-(4-fluorobenzyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine: an anticancer drug

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