• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Frontiers in Neuroanatomy >Differential Postnatal Expression of Neuronal Maturation Markers in the Dentate Gyrus of Mice and Rats
【24h】

Differential Postnatal Expression of Neuronal Maturation Markers in the Dentate Gyrus of Mice and Rats

机译：小鼠和大鼠齿状回中神经元成熟标记物的产后差异表达。

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The dentate gyrus (DG) is a unique structure of the hippocampus that is distinguished by ongoing neurogenesis throughout the lifetime of an organism. The development of the DG, which begins during late gestation and continues during the postnatal period, comprises the structural formation of the DG as well as the establishment of the adult neurogenic niche in the subgranular zone (SGZ). We investigated the time course of postnatal maturation of the DG in male C57BL/6J mice and male Sprague-Dawley rats based on the distribution patterns of the immature neuronal marker doublecortin (DCX) and a marker for mature neurons, calbindin (CB). Our findings demonstrate that the postnatal DG is marked by a substantial maturation with a high number of DCX-positive granule cells (GCs) during the first two postnatal weeks followed by a progression toward more mature patterns and increasing numbers of CB-positive GCs within the subsequent 2 weeks. The most substantial shift in maturation of the GC population took place between P7 and P14 in both mice and rats, when young, immature DCX-positive GCs became confined to the innermost part of the GC layer (GCL), indicative of the formation of the SGZ. These results suggest that the first month of postnatal development represents an important transition phase during which DG neurogenesis and the maturation course of the GC population becomes analogous to the process of adult neurogenesis. Therefore, the postnatal DG could serve as an attractive model for studying a growing and functionally maturing neural network. Direct comparisons between mice and rats revealed that the transition from immature DCX-positive to mature CB-positive GCs occurs more rapidly in the rat by approximately 4–6 days. The remarkable species difference in the speed of maturation on the GC population level may have important implications for developmental and neurogenesis research in different rodent species and strains.
机译：齿状回（DG）是海马的独特结构，其特征是在整个生物体的整个生命过程中不断发生神经发生。 DG的发育始于妊娠后期，并持续至产后。这包括DG的结构形成以及在颗粒下带（SGZ）中的成年神经源利基的建立。我们基于未成熟神经元标记双皮质素（DCX）和成熟神经元标记钙蛋白（CB）的分布模式，研究了雄性C57BL / 6J小鼠和雄性Sprague-Dawley大鼠中DG产后成熟的时间过程。我们的发现表明，出生后的DG的特征是在出生后的前两周内大量DCX阳性颗粒细胞（GC）大量成熟，随后逐渐向成熟模式发展，并且CB阳性GC的数量不断增加随后的2周。当年轻的，未成熟的DCX阳性GC局限于GC层（GCL）的最内层时，GC种群成熟的最大变化发生在小鼠和大鼠的P7和P14之间。 SGZ。这些结果表明，产后发育的第一个月代表了一个重要的过渡阶段，在此期间DG神经发生和GC群体的成熟过程变得类似于成人神经发生的过程。因此，产后DG可以作为研究增长中且功能成熟的神经网络的有吸引力的模型。小鼠与大鼠之间的直接比较表明，从不成熟的DCX阳性到成熟的CB阳性GC的转变在大鼠中发生的速度大约为4至6天。 GC种群水平上成熟速度上显着的物种差异可能对不同啮齿动物物种和品系的发育和神经发生研究具有重要意义。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号