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首页> 外文期刊>Medical science monitor : >Mycoplasma pneumoniae in adult community-acquired pneumonia increases matrix metalloproteinase-9 serum level and induces its gene expression in peripheral blood mononuclear cells
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Mycoplasma pneumoniae in adult community-acquired pneumonia increases matrix metalloproteinase-9 serum level and induces its gene expression in peripheral blood mononuclear cells

机译：成人社区获得性肺炎支原体肺炎可增加基质金属蛋白酶9血清水平并诱导其在外周血单个核细胞中的基因表达

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Background:The objective of this study was to assess the concentration of metalloproteinase-2 (MMP-2) and metalloproteinase-9 (MMP-9) in peripheral circulation and their mRNA expression in peripheral blood mononuclear cells (PBMCs) in patients with CAP caused by M. pneumoniae.Material/Methods:We prospectively analyzed MMPs in 40 hospitalized patients with M. pneumoniae CAP on admission, and in the convalescent phase. Twenty healthy men were used as controls. Quantitative real-time PCR and ELISA tests were used.Results:MMP-9 mRNA expression in PBMCs was increased in the acute phase of illness compared to the control group as well as in convalescent phase in which case it was statistically significant (Mann-Whitney; p=0.028). The same was found for MMP-9 plasma levels (Mann-Whitney test; p0.001; p=0.001). Circulating MMP-2 concentration in acute patients was significantly lower than in the control group and convalescent phase (Mann-Whitney test; p=0.012; p=0.001), while no MMP-2 mRNA expression was found in PBMCs. The plasma level of MMP-9 correlated with leukocyte count in peripheral circulation (r=0.67, p0.001).Conclusions:We conclude that M. pneumoniae in adult CAP induces activity of MMP-9 in peripheral blood circulation.
机译：背景：本研究的目的是评估CAP引起的CAP患者外周血中金属蛋白酶2（MMP-2）和金属蛋白酶9（MMP-9）的浓度及其在外周血单个核细胞（PBMC）中的mRNA表达。材料/方法：前瞻性分析了入院时和恢复期住院的40例肺炎支原体CAP患者的MMPs。二十名健康男性用作对照。结果：与对照组相比，在疾病的急性期和康复期，PBMCs中MMP-9 mRNA的表达均增加（在统计学上具有统计学意义（Mann-Whitney） ; p = 0.028）。对于MMP-9血浆水平发现了相同的结果（Mann-Whitney测试; p ＜0.001; p ＝ 0.001）。急性患者的循环中MMP-2浓度明显低于对照组和恢复期（Mann-Whitney检验; p = 0.012; p = 0.001），而PBMC中未发现MMP-2 mRNA表达。结论：成人CAP中的肺炎支原体可诱导外周血MMP-9的活性，其血浆MMP-9水平与外周血白细胞计数相关（r = 0.67，p <0.001）。

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