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首页> 外文期刊>Microbiologia Medica >Epidemiological and molecular surveillance of influenza and respiratory syncytial viruses in children with acute respiratory infections (2004/2005 season)
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Epidemiological and molecular surveillance of influenza and respiratory syncytial viruses in children with acute respiratory infections (2004/2005 season)

机译：急性呼吸道感染儿童的流感和呼吸道合胞病毒的流行病学和分子监测（2004/2005季节）

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Objective. During the 2004/2005 influenza season an active virological surveillance of influenza viruses and respiratory syncytial virus (RSV) was carried out to monitor the epidemiologic trend of acute respiratory infections (ARI) in the paediatric community. Materials and methods. 100 patients (51 males, 49 females; mean age: 19 months), either treated at the Emergency Unit or hospitalized in the Pediatric Unit of “San Carlo Borromeo Hospital” (Milan), reporting symptoms related to ARI were enrolled. Pharyngeal swabs were collected for virological investigation by: 1) multiplexnested- PCR for the simultaneous identification of both influenza A and B viruses and RSV; 2) multiplex-nested- PCR for the subtyping of influenza A viruses (H1 and H3). Results. 12% (12/100) subjects were infected with influenza A virus, 4% (4/100) with influenza B virus and 14 (14%) with RSV. Of all the 12 influenza A positive samples 4 (33.3%) belonged to subtype H1 and 8 (66.7%) to subtype H3. Bronchiolitis and bronchitis episodes were significantly higher among RSV-infected subjects than among influenza- infected subjects (42.8% vs 6.2%; p<0.05 and 35.7% vs 6.2%; p<0.05, respectively). Pneumonia episodes occurred similarly both in influenza-infected children and in RSV-infected ones. Conclusions. During the 2004/2005 influenza season, influenza viruses and RSV were liable for high morbidity among paediatric subjects.The present study underlies the importance of planning an active surveillance of respiratory viral infections among paediatric cases requiring hospitalization due to ARI.A thorough analysis of target population features, of viruses antigenic properties and seasonality will be decisive in the evaluation of each clinical event.
机译：目的。在2004/2005流感季节，对流感病毒和呼吸道合胞病毒（RSV）进行了积极的病毒学监测，以监测小儿社区急性呼吸道感染（ARI）的流行病学趋势。材料和方法。研究入选了100例患者（男51例，女49例;平均年龄：19个月），这些患者在“ San Carlo Borromeo医院”（米兰）的急诊室接受治疗或在儿科住院，并报告了与ARI相关的症状。通过以下方法收集咽拭子用于病毒学研究：1）多重PCR-同时鉴定甲型和乙型流感病毒和RSV; 2）用于甲型流感病毒（H1和H3）亚型的多重嵌套PCR。结果。 12％（12/100）的受试者感染了甲型流感病毒，4％（4/100）的乙型流感病毒感染了14（14％）的RSV。在所有12种甲型流感阳性样本中，有4种（33.3％）属于H1亚型，而8种（66.7％）属于H3亚型。 RSV感染受试者的毛细支气管炎和支气管炎发作明显高于流感感染受试者（分别为42.8％和6.2％; p <0.05和35.7％vs 6.2％; p <0.05）。肺炎发作在受流感感染的儿童和受RSV感染的儿童中相似地发生。结论。在2004/2005流感季节，流感病毒和RSV对儿科患者的高发病率负有责任。本研究的基础是，计划对因ARI而需要住院的儿科患者进行呼吸道病毒感染的主动监测。病毒的种群特征，抗原特性和季节性将在每个临床事件的评估中起决定性作用。

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