...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Molecular brain >Cortical parvalbumin and somatostatin GABA neurons express distinct endogenous modulators of nicotinic acetylcholine receptors
【24h】

Cortical parvalbumin and somatostatin GABA neurons express distinct endogenous modulators of nicotinic acetylcholine receptors

机译：皮质小白蛋白和生长抑素GABA神经元表达不同的内源性烟碱型乙酰胆碱受体调节剂

获取原文
   

获取外文期刊封面封底 >>

       
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Background Inhibition from GABAergic interneurons in brain circuits is a critical component of cognitive function. This inhibition is regulated through a diverse network of neuromodulation. A number of recent studies suggest that one of the major regulators of interneuron function is nicotinic acetylcholinergic transmission and dysregulation of both systems is common in psychiatric conditions. However, how nicotinic modulation impacts specific subpopulations of diverse GABAergic interneurons remains in question. One potential way of conferring specificity to the convergence of GABAergic and nicotinic signaling is through the expression of a unique family of nicotinic acetycholine receptor modulators, the Lynx family. The present study sought to identify members of the Lynx family enriched in cortical interneurons and to elucidate subpopulations of GABAergic neurons that express unique nicotinic modulators. Results We utilize double fluorescence in situ hybridization to examine the interneuronal expression of the Lynx family in adult mouse visual cortex. We find that two of the Lynx family members, Lynx1 and Lypd6, are enriched in interneuron populations in cortex. Nearly all parvalbumin interneurons express Lynx1 but we did not detect Lypd6 in this population. Conversely, in somatostatin interneurons Lypd6 was found in a subset localized to deep cortical layers but no somatostatin neurons show detectable levels of Lynx1. Using a combination of genetic and viral manipulations we further show that a subpopulation of deep-layer cortico-cortical long-range somatostatin neurons also express Lypd6. Conclusions This work shows that distinct subpopulations of GABAergic interneurons express unique Lynx family members. The pattern of expression of Lynx family members within interneurons places them in a unique position to potentially regulate the convergence of GABAergic and nicotinic systems, dysfunction of which are characteristic of psychiatric disorders.
机译：背景抑制脑电路中的GABA能神经元是认知功能的关键组成部分。通过多种神经调节网络来调节这种抑制作用。最近的许多研究表明，中枢神经元功能的主要调节剂之一是烟碱乙酰胆碱能传递，在精神病患者中这两个系统的调节异常是常见的。然而，烟碱调节如何影响不同的GABA能中间神经元的特定亚群仍是一个问题。赋予GABA能和烟碱信号转导特异性特异性的一种潜在方式是通过表达独特的烟碱乙酰胆碱受体调节剂家族Lynx家族。本研究试图确定Lynx家族中富含皮质中间神经元的成员，并阐明表达独特烟碱调节剂的GABA能神经元的亚群。结果我们利用双重荧光原位杂交技术检测了成年小鼠视觉皮层Lynx家族的神经元间表达。我们发现Lynx家族的两个成员Lynx1和Lypd6富含皮质中神经元。几乎所有小白蛋白中间神经元都表达Lynx1，但我们在此人群中未检测到Lypd6。相反，在生长抑素中间神经元中，Lypd6在局部位于深皮质层的子集中发现，但没有生长抑素神经元显示出可检测到的Lynx1水平。使用遗传和病毒操作的组合，我们进一步表明，深层皮层皮质远程生长抑素神经元的亚群也表达Lypd6。结论这项工作表明，GABA能中间神经元的不同亚群表达了独特的Lynx家族成员。 Lynx家族成员在中间神经元中的表达方式使它们处于独特的位置，以潜在地调节GABA能和烟碱系统的趋同，其功能障碍是精神疾病的特征。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号