• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>NeuroImage: Clinical >Intrinsic brain networks normalize with treatment in pediatric complex regional pain syndrome
【24h】

Intrinsic brain networks normalize with treatment in pediatric complex regional pain syndrome

机译：小儿复杂区域性疼痛综合征的治疗使内在神经网络正常化

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Pediatric complex regional pain syndrome (P-CRPS) offers a unique model of chronic neuropathic pain as it either resolves spontaneously or through therapeutic interventions in most patients. Here we evaluated brain changes in well-characterized children and adolescents with P-CRPS by measuring resting state networks before and following a brief (median?=?3?weeks) but intensive physical and psychological treatment program, and compared them to matched healthy controls. Differences in intrinsic brain networks were observed in P-CRPS compared to controls before treatment (disease state) with the most prominent differences in the fronto-parietal, salience, default mode, central executive, and sensorimotor networks. Following treatment, behavioral measures demonstrated a reduction of symptoms and improvement of physical state (pain levels and motor functioning). Correlation of network connectivities with spontaneous pain measures pre- and post-treatment indicated concomitant reductions in connectivity in salience, central executive, default mode and sensorimotor networks (treatment effects). These results suggest a rapid alteration in global brain networks with treatment and provide a venue to assess brain changes in CRPS pre- and post-treatment, and to evaluate therapeutic effects. Highlights ? Pediatric complex regional pain syndrome (CRPS) alters brain networks. ? Alterations are not equivalent to those observed in adults with CRPS. ? Identifying alterations might be relevant to determine treatment modalities. ? Intensive physical- and psycho-therapy reverses some but not all the changes.
机译：小儿复杂区域性疼痛综合征（P-CRPS）提供了一种独特的慢性神经性疼痛模型，因为它可以自发缓解或通过大多数患者的治疗干预来缓解。在这里，我们通过测量短暂（中位数=？3？周）但密集的心理和心理治疗程序之前和之后的静息状态网络，评估了特征明确的P-CRPS儿童和青少年的大脑变化，并将其与匹配的健康对照进行比较。与治疗前的对照（疾病状态）相比，在P-CRPS中观察到内在大脑网络的差异，在额顶叶，显着性，默认模式，中枢执行和感觉运动网络方面最明显。治疗后，行为措施证明症状减轻和身体状态改善（疼痛水平和运动功能）。治疗前和治疗后网络连接性与自发性疼痛测量的相关性表明，显着性，中枢执行，默认模式和感觉运动网络（治疗效果）的连接性随之降低。这些结果表明治疗后全球脑网络的快速变化，为评估CRPS治疗前后的脑部变化以及评估治疗效果提供了场所。强调 ？小儿复杂区域性疼痛综合征（CRPS）会改变大脑网络。 ？这种变化并不等同于在CRPS成人中观察到的变化。 ？识别改变可能与确定治疗方式有关。 ？密集的物理和心理治疗可以逆转一些但并非全部的变化。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号