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首页> 外文期刊>North American Journal of Medical Sciences >Secondary gliosarcoma after the treatment of primary glioblastoma multiforme
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Secondary gliosarcoma after the treatment of primary glioblastoma multiforme

机译：原发性胶质母细胞瘤治疗后继发性青光眼肉瘤

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Context:Gliosarcoma is a rare variant of glioblastoma multiforme containing distinct gliomatous and sarcomatous components. Gliosarcoma comprise 1.8–8% of glioblastoma multiforme and are clinically similar to them, affecting adults in the fourth and sixth decades of life, with a higher proportion found in males. The survival for patients with Gliosarcoma is equally poor as for those with glioblastoma multiforme, and there is a greater propensity for extracranial metastasis in Gliosarcoma. Clinical treatment-related experience reported in the literature is limited, and Gliosarcoma are currently treated in a similar fashion to glioblastoma multiforme, with modalities including tumor resection, postoperative radiation therapy, and chemotherapy. Gliosarcoma can arise secondarily, after conventional adjuvant treatment of high-grade glioma. The current literature on the occurrence of secondary gliosarcoma after glioblastoma multiforme is limited, with only 54 reported cases.Case Report:The authors present a 48-year-old Caucasian male who had previously received postoperative combined radiation and temozolomide chemotherapy for glioblastoma multiforme. After a free disease period of 9 months the disease recurs as Gliosarcoma. The patient underwent a Total surgical excision and received chemotherapy with a basis of bevacizumab and irinotecan. The patient died from tumor progression 5 months after gliosarcoma diagnosis.Conclusion:The poor survival of patients with secondary gliosarcoma who had previously received combined radiation and temozolomide chemotherapy for glioblastoma multiforme may reflect a unique molecular profile of glioblastoma multiforme that eventually recurs as secondary gliosarcoma. We have to keep in mind the possibility of gliosarcomatous change in the recurrence of malignant glioma. Awareness of this pathological entity will allow more rapid diagnosis and treatment.
机译：背景：神经胶质肉瘤是多形性胶质母细胞瘤的罕见变体，包含明显的胶质瘤和肉瘤成分。胶质肉瘤占多形性胶质母细胞瘤的1.8–8％，并且在临床上与它们相似，在成年后的第四和第六个十年中影响成年人，其中男性比例更高。胶质肉瘤患者的生存与多形性胶质母细胞瘤患者的生存同样差，并且胶质肉瘤的颅外转移倾向更大。文献中报道的与临床治疗相关的经验有限，目前以与多形性胶质母细胞瘤相似的方式治疗胶质肉瘤，其方式包括肿瘤切除，术后放疗和化疗。在对高级别神经胶质瘤进行常规辅助治疗后，继发性胶质肉瘤。目前关于多形性胶质母细胞瘤继发继发性胶质肉瘤的文献报道有限，仅报道了54例。病例报告：作者介绍了一位48岁的白人男性，该男性先前曾接受过联合放疗和替莫唑胺联合化疗用于多形性胶质母细胞瘤。经过9个月的免费发病期后，该疾病复发为胶质肉瘤。患者接受了全外科手术切除，并接受了贝伐单抗和伊立替康的化疗。该患者在诊断为胶质肉瘤后5个月死于肿瘤进展。我们必须谨记，恶性神经胶质瘤复发中可能会出现滑膜肉瘤改变。意识到这种病理学实体将可以更快速地进行诊断和治疗。

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