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Resistin and visfatin concentrations are related to central obesity and inflammation in Brazilian children

机译：抵抗素和维斯汀的浓度与巴西儿童的中心性肥胖和炎症有关

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BackgroundThe evidence that cardiovascular disease begins in childhood and adolescence, especially in the presence of excess weight, is associated with dysfunction on adipokine pro-inflammatory secretion. These affect glucose metabolism and lead to other complications related to insulin resistance and cardiovascular disease. This study assessed the association of anthropometric and metabolic parameters related to obesity, cardiovascular risk, and insulin resistance with concentrations of resistin and visfatin, in children. MethodsA cross-sectional study was developed with 178 children of 6–10?years old enrolled in public city schools. Anthropometric data, composition body, clinical, and biochemical were measured according to standard procedures. We used multiple regression models by stepwise method to evaluate the associations of resistin and visfatin with variables of interest. ResultsIn healthy weight children, resistin was associated with LDL cholesterol, visfatin, atherogenic index, and waist-to-height ratio, whereas in obese children resistin was associated with visfatin and interaction between conicity index and HOMA-AD. Furthermore, in healthy weight children, visfatin was associated to resistin and triceps skinfold thickness and negatively associated to HOMA-AD, while in obese ones visfatin was associated with waist-to-height ratio, atherogenic index, resistin, and interaction between trunk adiposity index and adiponectin and was negatively associated with the HOMA-IR index. ConclusionsOur study shows an association between anthropometric and biochemical variables related to visceral fat and inflammation. These results suggest the resistin and visfatin as good pro-inflammatory markers. In addition, both adipokines are strongly related to central obesity, in children.
机译：背景心血管疾病始于儿童和青少年期的证据，尤其是在体重过重的情况下，与脂肪因子促炎性分泌功能障碍有关。这些会影响葡萄糖代谢，并导致其他与胰岛素抵抗和心血管疾病有关的并发症。这项研究评估了与肥胖，心血管疾病风险和胰岛素抵抗相关的人体测量学和代谢参数与儿童抵抗素和维斯汀的浓度之间的关系。方法采用横断面研究方法，对178名6-10岁的儿童入读了公立城市学校进行了研究。根据标准程序测量人体测量数据，成分，临床和生化指标。我们通过逐步方法使用了多个回归模型来评估抵抗素和visfatin与目标变量的关联。结果在健康体重的儿童中，抵抗素与低密度脂蛋白胆固醇，visfatin，动脉粥样硬化指数和腰高比有关，而在肥胖儿童中，抵抗素与visfatin和锥度指数与HOMA-AD之间的相互作用有关。此外，在健康体重的儿童中，visfatin与抵抗素和三头肌的皮褶厚度相关，而与HOMA-AD呈负相关，而在肥胖儿童中，visfatin与腰高比，动脉粥样硬化指数，抵抗素以及躯干肥胖指数之间的相互作用有关。和脂联素与HOMA-IR指数呈负相关。结论我们的研究表明与内脏脂肪和炎症相关的人体测量学和生化指标之间存在关联。这些结果表明抵抗素和visfatin是良好的促炎标记。此外，儿童中的两种脂肪因子都与中枢性肥胖密切相关。

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