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首页> 外文期刊>Nutrition, metabolism, and cardiovascular diseases: NMCD >Association of circulating visfatin concentrations with insulin resistance and low-grade inflammation after dietary energy restriction in Spanish obese non-diabetic women: Role of body composition changes
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Association of circulating visfatin concentrations with insulin resistance and low-grade inflammation after dietary energy restriction in Spanish obese non-diabetic women: Role of body composition changes

机译：西班牙肥胖非糖尿病女性中饮食中能量消耗后循环visfatin浓度与胰岛素抵抗和低度炎症的关系：身体成分变化的作用

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Background and Aims: To assess the influence of body composition changes on circulating serum visfatin after following 12 weeks of energy restricted diet intervention. We also examined the possible role of visfatin in glucose metabolism and in obesity-associated low-grade inflammation. Methods and Results: A total of 78 obese (BMI 34.0 ± 2.8 kg/m 2) women aged 36.7±7 y volunteered to participate in the study. We measured by DXA body fat mass (FM) and lean mass (LM). Fasting serum visfatin, glucose, insulin, adiponectin, leptin, IL-1β, IL-6, IL-8, TNF-α and CRP concentrations were analyzed before and after the intervention and HOMA and QUIKI indexes were calculated. Mean weight loss 7.7 ± 3.0 kg and HOMA decreased in 24 ± 35%. Serum visfatin concentration change was negatively associated with LM difference (P 0.05), whereas no significant relationship was observed with FM changes after energy restricted diet intervention. Changes in circulating serum visfatin levels were significantly and inversely associated with HOMA-IR (P 0.01) and positively with QUICKI index (P 0.02) after energy restricted diet intervention, regardless of achieved body weight loss. We did not find any significant association between changes in visfatin levels and IL-1β, IL-6, IL-8, TNF-α and CRP levels after dietary intervention (all P 0.2). Conclusion: Circulating visfatin concentration is associated with sensitivity improvement achieved after energy restricted diet intervention induced weight loss. Furthermore, LM changes could be an influencing factor on visfatin concentrations and consequently, on the improvement of insulin sensitivity after weight loss in obese non-diabetic women. Our findings did not provide any evidence for a role of visfatin increase on low-grade inflammation after weight loss.
机译：背景与目的：评估能量限制饮食干预后12周后，身体成分变化对循环血清visfatin的影响。我们还检查了visfatin在葡萄糖代谢和肥胖相关的轻度炎症中的可能作用。方法和结果：共有78名36.7±7岁的肥胖（BMI 34.0±2.8 kg / m 2）妇女自愿参加了这项研究。我们通过DXA人体脂肪量（FM）和瘦体重（LM）进行了测量。分析干预前后的空腹血清visfatin，葡萄糖，胰岛素，脂联素，瘦素，IL-1β，IL-6，IL-8，TNF-α和CRP浓度，并计算HOMA和QUIKI指数。平均体重减轻7.7±3.0 kg，HOMA降低24±35％。能量限制饮食干预后，血清visfatin浓度变化与LM差异呈负相关（P <0.05），而与FM变化无显着关系。能量限制饮食干预后，无论是否达到体重减轻，循环血清visfatin水平的变化与HOMA-IR呈显着负相关（P <0.01），与QUICKI指数呈正相关（P <0.02）。在饮食干预后，我们未发现visfatin水平与IL-1β，IL-6，IL-8，TNF-α和CRP水平之间的任何显着相关性（所有P> 0.2）。结论：能量限制饮食干预导致体重减轻后，循环中的visfatin浓度与敏感性改善有关。此外，LM的变化​​可能是影响visfatin浓度的因素，因此可能是肥胖非糖尿病女性减肥后胰岛素敏感性改善的因素。我们的发现没有提供任何证据表明维斯法汀在减肥后增加对低度炎症的作用。

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