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首页> 外文期刊>Research Journal of Medical Sciences >Study of Matricaria recutita and Vincristine Effects on PTZ-Induced Seizure Threshold in Mice
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Study of Matricaria recutita and Vincristine Effects on PTZ-Induced Seizure Threshold in Mice

机译：母菊和长春新碱对PTZ诱发的癫痫发作阈值的影响的研究

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Studies have shown that chamomile contains significant amounts of free amino acids and flavonoids that have anti-inflammatory, anti-seizure and anti fever effects. Vincristine-based chemotherapy is the major treatment of Hodgkin?s and non-Hodgkin?s lymphoma, nephroblastoma and acute lymphoblastic leukemia. Studies showed that vincristine has neuropathic effects in humans and different animal models. In this study, anticonvulsant effects of hydroalcoholic extract of Matricaria recutita and convulsant effects of vincristine using the standard method of chemical seizure caused by Pentylenetetrazole (PTZ) in mice was investigated. For this propose first group, received normal saline, group II received Matricaria recutita hydroalcoholic extract (200 mg kg-1) as intraperitoneal, vincristine group III received (10 μg/kg/day) intravenously for 10 days in the fourth group of Matricaria recutita hydroalcoholic extract plus vincristine was used and the subsequent seizure threshold was determined for each group. The results of this study showed that PTZ-induced seizure threshold in control mice was 35.52±0.87 mg kg-1 and chamomile hydroalcoholic extract significantly (p<0.05) increased the PTZ seizure threshold. Seizure threshold in the vincristine group significantly (p<0.05) decreased. Simultaneous uses of vincristine and Matricaria recutita extract caused to significantly increased seizure threshold (p<0.05) in vincristine taking group. The existence of several types of antioxidants and flavonoids in Matricaria recutita that have antioxidant effects in addition to anticonvulsant effects of this plant are set to reduce the neuropathic effects of vincristine. However, the anticonvulsant effect in human and material mechanisms involved need further investigations.
机译：研究表明，洋甘菊含有大量的游离氨基酸和类黄酮，具有抗炎，抗癫痫和抗发烧的作用。基于长春新碱的化疗是霍奇金淋巴瘤和非霍奇金淋巴瘤，肾母细胞瘤和急性淋巴细胞白血病的主要治疗方法。研究表明长春新碱对人类和其他动物模型具有神经病作用。在这项研究中，使用标准的method四唑（PTZ）引起的小鼠癫痫发作的标准方法，研究了美cut母水母提取物的抗惊厥作用和长春新碱的惊厥作用。对于该提议的第一组，接受生理盐水，第二组接受腹膜内注射毛母草的水醇提取物（200 mg kg-1），腹膜内注射长春新碱，第四组毛囊白内酯的静脉注射（10μg/ kg /天），持续10天使用水醇提取物加长春新碱，然后确定每组的癫痫发作阈值。这项研究的结果表明，PTZ诱发的对照组癫痫发作阈值为35.52±0.87 mg kg-1，洋甘菊水醇提取物显着（p <0.05）提高了PTZ癫痫发作的阈值。长春新碱组的癫痫发作阈值明显降低（p <0.05）。长春新碱和母菊提取物的同时使用导致长春新碱服用组的癫痫发作阈值显着增加（p <0.05）。为了提高长春新碱的神经病作用，在Ma母中存在几种具有抗氧化作用的抗氧化剂和黄酮类化合物，除了具有抗惊厥作用外，还具有抗氧化作用。然而，在涉及的人和物质机制中的抗惊厥作用需要进一步研究。

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