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首页> 外文期刊>Romanian Journal of Biophysics >ALTERATION OF SOME BIOPHYSICAL PROPERTIES OF ERYTHROCYTES OF SILICOTIC PATIENTS
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ALTERATION OF SOME BIOPHYSICAL PROPERTIES OF ERYTHROCYTES OF SILICOTIC PATIENTS

机译：矽肺患者红细胞某些生物物理特性的改变

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Long-term exposure to silica has been reported to be the principal cause of silicosis which is perhaps the best-known occupational disease. In the present study, we investigated plasma malondialdehyde (MDA) level as an index of lipid peroxidation and erythrocyte reduced glutathione (GSH), superoxide dismutase (SOD) and glutathione peroxidase (GPx) activities levels as an index of antioxidant status in silicotic patients. The exposed workers were divided into three categories according to the intensity of their exposure, which had been weak, moderate and strong. Results showed that there is a significant decrease of erythrocyte GSH, GPx and SOD as well as significant increase in MDA level in comparison with the controls. Moreover, a functional disturbance in RBC membrane occurred as revealed by alteration in hemorheological and dielectric properties. Thus the mentioned techniques seem to be reliable, rapid and sensitive for detecting erythrocytes damage cells and fulfils the requirements of biological markers for silica exposure.
机译：据报道，长期接触二氧化硅是矽肺病的主要原因，矽肺病可能是最著名的职业病。在本研究中，我们调查血浆丙二醛（MDA）水平作为脂质过氧化的指标，红细胞还原型谷胱甘肽（GSH），超氧化物歧化酶（SOD）和谷胱甘肽过氧化物酶（GPx）活性水平作为矽肺患者抗氧化剂状态的指标。根据暴露的强度，暴露工人分为弱，中和强三类。结果显示，与对照组相比，红细胞GSH，GPx和SOD显着降低，MDA水平显着提高。此外，如血液流变学和介电性质的改变所揭示，RBC膜发生了功能紊乱。因此，所提及的技术对于检测红细胞损伤细胞似乎是可靠，快速和灵敏的，并且满足了暴露于二氧化硅的生物标记的要求。

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