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首页> 外文期刊>Open Journal of Respiratory Diseases >Changes in Adenosine Metabolism in Asthma. A Study on Adenosine, 5'-NT, Adenosine Deaminase and Its Isoenzyme Levels in Serum, Lymphocytes and Erythrocytes
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Changes in Adenosine Metabolism in Asthma. A Study on Adenosine, 5'-NT, Adenosine Deaminase and Its Isoenzyme Levels in Serum, Lymphocytes and Erythrocytes

机译：哮喘中腺苷代谢的变化。血清，淋巴细胞和红细胞中腺苷，5'-NT，腺苷脱氨酶及其同工酶水平的研究

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Background: Adenosine deaminase (ADA) and 5'-nucleotidase (5'-NT) play a crucial role in adenosine metabolism in healthy individuals. Adenosine is an inflammatory mediator of asthma. Changes in adenosine metabolism and role of ADA and 5'-NT in regulating adenosine level in asthmatics and correlation of these changes with severity of asthma are not clearly understood. Methods: In this study, we screened 5217 patients, of which 2416 were diagnosed with asthma. Further, of 2416 asthmatics, only 45 patients who strictly fulfilled the selection criteria were enrolled in the study. The patients were classified into mild, moderate and severe persistent groups; each group consisted of fifteen patients. Fifteen healthy subjects served as controls. Adenosine levels and activities of 5'-NT, total ADA, ADA1 and ADA2 in serum, lymphocytes and erythrocytes were determined. The data were analysed statistically and p vice versa.
机译：背景：腺苷脱氨酶（ADA）和5'-核苷酸酶（5'-NT）在健康个体的腺苷代谢中起关键作用。腺苷是哮喘的炎性介质。尚不清楚哮喘患者中腺苷代谢的变化以及ADA和5'-NT在调节腺苷水平中的作用以及这些变化与哮喘严重程度的相关性。方法：在这项研究中，我们筛选了5217例患者，其中2416例被诊断患有哮喘。此外，在2416名哮喘患者中，只有45名严格满足选择标准的患者入选了该研究。将患者分为轻度，中度和重度持续组。每组由十五名患者组成。十五名健康受试者作为对照。测定血清，淋巴细胞和红细胞中腺苷水平和5'-NT，总ADA，ADA1和ADA2的活性。对数据进行统计分析，反之亦然。

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