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首页> 外文期刊>Sao Paulo Medical Journal >A study of pulmonary function in end-stage renal disease patients on hemodialysis: a cross-sectional study
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A study of pulmonary function in end-stage renal disease patients on hemodialysis: a cross-sectional study

机译：终末期肾病患者血液透析的肺功能研究：一项横断面研究

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ABSTRACT BACKGROUND: The aim here was to study acute effects of hemodialysis among end-stage renal disease (ESRD) patients. DESIGN AND SETTING: Prospective study in tertiary-level care center. METHODS: Fifty ESRD patients undergoing hemodialysis were studied. Spirometric pulmonary function tests were performed before and after four-hour hemodialysis sessions. RESULTS: The patients’ average age was 45.8 ± 10.0 years; 64% were males and 64% had normal body mass index. Anemia (94%) and hypoalbuminemia (72%) were common. Diabetes mellitus (68%), hypertension (34%) and coronary artery disease (18%) were major comorbidities. Forty-five patients (90%) had been on hemodialysis for six months to three years. The patients’ pre-dialysis mean forced vital capacity (FVC) and forced expiratory volume in 1 second (FEV1) were below normal: 45.8 ± 24.9% and 43.5 ± 25.9% of predicted, respectively. After hemodialysis, these increased significantly, to 51.1 ± 23.4% and 49.3 ± 25.5% of predicted, respectively (P 0.05). The pre-dialysis mean forced expiratory flow 25-75% was 50.1 ± 31% and increased significantly, to 56.3 ± 31.6% of predicted (P < 0.05). The mean peak expiratory flow was below normal (43.8 ± 30.7%) and increased significantly, to 49.1 ± 29.9% of predicted (P < 0.05). Males and females showed similar directions of change after hemodialysis. CONCLUSIONS: Pulmonary function abnormalities are common among ESRD patients. Comparison of pre and post-hemodialysis parameters showed significant improvements, but normal predicted values were still not achieved.
机译：摘要背景：本研究的目的是研究终末期肾病（ESRD）患者血液透析的急性作用。设计与环境：在三级护理中心进行前瞻性研究。方法：对50例接受血液透析的ESRD患者进行了研究。在四个小时的血液透析之前和之后进行肺功能肺功能测试。结果：患者的平均年龄为45.8±10.0岁。男性占64％，体重指数正常。贫血（94％）和低白蛋白血症（72％）很常见。糖尿病（68％），高血压（34％）和冠心病（18％）是主要合并症。四十五名患者（90％）接受了血液透析六个月至三年。患者的透析前平均强迫肺活量（FVC）和1秒强迫呼气量（FEV1）低于正常值：分别为预期的45.8±24.9％和43.5±25.9％。血液透析后，这些值显着增加，分别达到预期值的51.1±23.4％和49.3±25.5％（P 0.05）。透析前的平均强制呼气流量为25-75％，为50.1±31％，并显着增加，达到预期的56.3±31.6％（P <0.05）。平均呼气峰值流量低于正常水平（43.8±30.7％），并且显着增加，达到预期的49.1±29.9％（P <0.05）。血液透析后，男性和女性表现出相似的变化方向。结论：肺功能异常在ESRD患者中很常见。血液透析前后参数的比较显示出显着改善，但仍未达到正常的预测值。

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