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首页> 外文期刊>Schizophrenia research and treatment >QTc Prolongation in Patients Acutely Admitted to Hospital for Psychosis and Treated with Second Generation Antipsychotics
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QTc Prolongation in Patients Acutely Admitted to Hospital for Psychosis and Treated with Second Generation Antipsychotics

机译：急性入院并接受第二代抗精神病药治疗的患者的QTc延长

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QTc interval prolongation is a side effect of several antipsychotic drugs, with associated risks of torsade de pointes arrhythmias and sudden cardiac death. There is an ongoing debate of whether or not electrocardiogram (ECG) assessments should be mandatory in patients starting antipsychotic drugs. To investigate QTc prolongation in a clinically relevant patient group 171 adult patients acutely admitted to an emergency ward for psychosis were consecutively recruited. ECGs were recorded at baseline and then at discharge or after 6 weeks at the latest (discharge/6 weeks), thus reflecting the acute phase treatment period. The mean QTc interval was 421.1 (30.4) ms at baseline and there was a positive association between the QTc interval and the agitation score whereas the QTc interval was inversely associated with the serum calcium level. A total of 11.6% had abnormally prolonged QTc intervals and another 14.3% had borderline prolongation. At discharge/6 weeks, the corresponding proportions were reduced to 4.2% and 5.3%, respectively. The reduction of the proportion with prolonged QTc intervals reached statistical significance (chi-square exact test:P=0.046). The finding of about one-quarter of the patients with borderline or prolonged QTc intervals could indicate mandatory ECG recordings in this population. This trial is registered with ClinicalTrials.gov ID:NCT00932529.
机译：QTc间隔延长是几种抗精神病药物的副作用，伴有尖锐度心律失常和突发性心脏猝死的风险。对于开始使用抗精神病药的患者是否应强制进行心电图（ECG）评估存在争议。为了研究临床相关患者组中的QTc延长，连续招募了171名急诊精神病急诊病房的成年患者。在基线时记录心电图，然后在出院时或最迟在6周后（出院/ 6周）记录ECG，因此反映了急性期治疗期。在基线时平均QTc间隔为421.1（30.4）ms，并且QTc间隔与搅拌分数之间存在正相关，而QTc间隔与血清钙水平呈负相关。共有11.6％的QTc间隔异常延长，另有14.3％的边界延长。在出院/ 6周时，相应的比例分别降至4.2％和5.3％。 QTc间隔延长时比例的降低达到统计学显着性（卡方精确检验：P = 0.046）。发现约四分之一的患者处于边缘性或QTc间隔延长的患者，可能表明该人群中有强制性的心电图记录。该试验已在ClinicalTrials.gov ID：NCT00932529中注册。

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