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首页> 外文期刊>Saudi Journal of Biological Sciences >Interference of phosphane copper (I) complexes of β-carboline with quorum sensing regulated virulence functions and biofilm in foodborne pathogenic bacteria: A first report
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Interference of phosphane copper (I) complexes of β-carboline with quorum sensing regulated virulence functions and biofilm in foodborne pathogenic bacteria: A first report

机译：食源性致病细菌中β-咔啉膦铜（I）配合物对群体感应调节的毒力功能和生物膜的干扰

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Foodborne pathogens are one of the major cause of food-related diseases and food poisoning. Bacterial biofilms and quorum sensing (QS) mechanism of cell–cell communication have also been found to be associated with several outbreaks of foodborne diseases and are great threat to food safety. Therefore, In the present study, we investigated the activity of three tetrahedrally coordinated copper(I) complexes against quorum sensing and biofilms of foodborne bacteria. All the three complexes demonstrated similar antimicrobial properties against the selected pathogens. Concentration below the MIC i.e. at sub-MICs all the three complexes interfered significantly with the quorum sensing regulated functions in C. violaceum (violacein), P. aeruginosa (elastase, pyocyanin and alginate production) and S. marcescens (prodigiosin). The complexes demonstrated potent broad-spectrum biofilm inhibition in Pseudomonas aeruginosa , E. coli , Chromobacterium violaceum , Serratia marcescens , Klebsiella pneumoniae and Listeria monocytogenes . Biofilm inhibition was visualized using SEM and CLSM images. Action of the copper(I) complexes on two key QS regulated functions contributing to biofilm formation i.e. EPS production and swarming motility was also studied and statistically significant reduction was recorded. These results could form the basis for development of safe anti-QS and anti-biofilm agents that can be utilized in the food industry as well as healthcare sector to prevent food-associated diseases.
机译：食源性病原体是与食物有关的疾病和食物中毒的主要原因之一。还发现细菌生物膜和细胞间通讯的群体感应（QS）机制与食源性疾病的多次爆发有关，对食品安全构成了巨大威胁。因此，在本研究中，我们研究了三种四面体配位的铜（I）配合物对群体感应和食源性细菌生物膜的活性。这三种复合物均对所选病原体表现出相似的抗微生物特性。低于MIC的浓度，即在亚MIC处，所有这三种复合物都严重干扰了紫胶衣藻（紫丁香素），铜绿假单胞菌（弹性蛋白酶，绿脓素和藻酸盐的产生）和marcescenss（prodigiosin）的群体感应调节功能。该复合物在铜绿假单胞菌，大肠杆菌，紫罗兰杆菌，粘质沙雷氏菌，肺炎克雷伯菌和单核细胞增生李斯特菌中显示出有效的广谱生物膜抑制作用。使用SEM和CLSM图像可视化生物膜抑制作用。还研究了铜（I）配合物在QS调控的两个关键功能上的作用，这些功能有助于生物膜的形成，即EPS产生和群运动，并记录了统计学上的显着降低。这些结果可为开发安全的抗QS和抗生物膜剂奠定基础，这些抗QS和抗生物膜剂可用于食品工业以及医疗保健部门，以预防食品相关疾病。

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