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首页> 外文期刊>Pain research & management: the journal of the Canadian Pain Society = journal de la socie?te? canadienne pour le traitement de la douleur >Effects of Gabapentinoids Premedication on Shoulder Pain and Rehabilitation Quality after Laparoscopic Cholecystectomy: Pregabalin versus Gabapentin
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Effects of Gabapentinoids Premedication on Shoulder Pain and Rehabilitation Quality after Laparoscopic Cholecystectomy: Pregabalin versus Gabapentin

机译：加巴喷丁类药物的处方对腹腔镜胆囊切除术后肩痛和康复质量的影响：普瑞巴林与加巴喷丁

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Introduction. Gabapentinoids are increasingly used in preoperative premedication despite controversial results. The aim of our study was to evaluate the effects of preemptive use of gabapentin or pregabalin on postoperative shoulder pain and rehabilitation quality after laparoscopic cholecystectomy. Methods. This is a clinical trial comparing the effects of a preoperative premedication with 600?mg of gabapentin or 150?mg of pregabalin versus placebo on postoperative pain and recovery quality after laparoscopic cholecystectomy. Premedication was taken 2 hours before the surgery beginning. Ninety patients were included and randomized into 3 groups (gabapentin, pregabalin, and placebo). The anesthetic protocol was the same for all patients. Primary endpoint was the shoulder pain intensity at the 48th postoperative hour. Secondary endpoints were postoperative nausea and vomiting (PONV), sleep quality during the first night, and the onset time for the first standing position. Results. During the first 48 postoperative hours, the gabapentin and pregabalin groups had significantly lower shoulder pain than the placebo group (). In gabapentinoids groups, the incidence of PONV was lower and the sleep quality during the first postoperative night was better with significant results. Mean Spiegel scores were 22.43?±?1.45, 22.30?±?1.44, and 17.17?±?1.66, respectively, in pregabalin, gabapentin, and placebo groups (). The delay for the first standing position was 14.9?±?4.9 hours in the pregabalin group, 9.7?±?3.6 hours in the gabapentin group, and 21.6?±?2.1 hours in the placebo group. No superiority was found between gabapentin and pregabalin. Conclusion. Preemptive premedication with gabapentinoids can enhance postoperative rehabilitation quality after laparoscopic cholecystectomy by reducing postoperative shoulder pain, decreasing PONV incidence, and improving sleep quality during the first postoperative night. This trial is registered with ClinicalTrial.gov (NCT03241875).
机译：介绍。尽管有争议的结果，加巴喷丁胺在术前用药中也越来越多。我们研究的目的是评估腹腔镜胆囊切除术后抢先使用加巴喷丁或普加巴林对术后肩痛和康复质量的影响。方法。这是一项临床试验，比较术前用600μg加巴喷丁或150μmg普瑞巴林与安慰剂相比，安慰剂对腹腔镜胆囊切除术后的疼痛和恢复质量的影响。在手术开始前2小时进行了预防用药。将90名患者纳入研究并随机分为3组（加巴喷丁，普瑞巴林和安慰剂）。所有患者的麻醉方案均相同。主要终点为术后第48小时的肩部疼痛强度。次要终点是术后恶心和呕吐（PONV），第一夜的睡眠质量以及首次站立姿势的开始时间。结果。在术后的前48小时内，加巴喷丁和普瑞巴林组的肩痛明显低于安慰剂组（）。在加巴喷丁类药物组中，PONV的发生率较低，术后首个晚上的睡眠质量较好，效果显着。普瑞巴林，加巴喷丁和安慰剂组的平均Spiegel评分分别为22.43±1.45、22.30±1.44和17.17±1.66（）。普瑞巴林组第一个站立姿势的延迟为14.9±±4.9小时，加巴喷丁组为9.7±±3.6小时，安慰剂组为21.6±±2.1小时。加巴喷丁和普瑞巴林之间没有发现优势。结论。加巴喷丁胺类药物的抢先用药可通过减轻术后肩部疼痛，降低PONV发生率并改善术后第一夜的睡眠质量来提高腹腔镜胆囊切除术后的康复质量。该试验已在ClinicalTrial.gov（NCT03241875）上注册。

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