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首页> 外文期刊>Pain Studies and Treatment >Temporal and Qualitative Differences in the Development of Allodynic Behaviors between Mice and Rats in a Peripheral Nerve Injury Model
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Temporal and Qualitative Differences in the Development of Allodynic Behaviors between Mice and Rats in a Peripheral Nerve Injury Model

机译：周围神经损伤模型中小鼠和大鼠异常痛行为发展的时间和质量差异

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摘要

The spared nerve injury (SNI) model of neuropathic pain was first developed by Decosterd and Woolf in 2000 in Sprague Dawley rats to enhance reproducibility of injury and behavioral responses resulting from a partial nerve injury. Given the differences in methodology and inconsistent behavioral data published in the SNI model of neuropathic pain in mice, and given that interspecies behavioral comparisons using the same peripheral nerve injury are presently lacking, in this study we assessed the development of mechanical and cold allodynia for five weeks in C57BL/6 mice and Sprague Dawley rats that underwent SNI. In rats and mice, the tibial and peroneal branches were ligated then severed, leaving the sural branch intact. By controlling several factors in the surgical procedure and behavioral tests, we found that rats developed and maintained strong mechanical and robust cold allodynia immediately following the injury that was maintained for the duration of the experiment (five weeks). In comparison, mice developed mechanical allodynia to a lesser magnitude which peaked at 2 weeks, but did not develop cold allodynia. We found both temporal and qualitative differences in the development of allodynic behaviors between SNI-mice and SNI-rats. Parallel analysis of interspecies differences can be exploited to reveal novel molecular players leading to divergent pain behaviors.
机译：2000年，Decosterd和Woolf首先在Sprague Dawley大鼠中开发了神经性疼痛的备用神经损伤（SNI）模型，以增强部分神经损伤引起的损伤的可再现性和行为反应。鉴于在小鼠神经性疼痛的SNI模型中发表的方法学差异和行为数据不一致，并且鉴于目前尚缺乏使用相同周围神经损伤的种间行为比较，在本研究中，我们评估了五个机械性和冷性异常性疼痛的发展在接受SNI的C57BL / 6小鼠和Sprague Dawley大鼠中进行了3周的实验。在大鼠和小鼠中，结扎胫骨和腓骨分支，然后切断，保留腓肠肌分支。通过控制外科手术程序和行为测试中的几个因素，我们发现大鼠在损伤持续了整个实验期间（五周）后立即发展并保持了强大的机械性和鲁棒性冷异常性疼痛。相比之下，小鼠发生机械性异常性疼痛的程度较小，在2周时达到峰值，但没有出现冷性异常性疼痛。我们发现SNI小鼠和SNI大鼠之间异常性行为的发展在时间和质量上都存在差异。可以利用种间差异的平行分析来揭示导致疼痛行为不同的新型分子。

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