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Patient preferences for antiretroviral therapy: effectiveness, quality of life, access and novel delivery methods

机译：患者对抗逆转录病毒疗法的偏爱：有效性，生活质量，获取途径和新颖的分娩方法

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Objective: The objective of this study was to understand patient preferences for contemporary antiretroviral therapy (ART) by focusing on three areas that have been understudied: minority patients (racial/ethnic and sexual minorities), experience with novel single-tablet regimens made available in the last 10 years, and patient concerns related to ART. The rationale was that identifying ART characteristics that are most desirable could inform provider prescribing practices, increase the use of patient-centered ART, maximize durability and ART adherence, and ultimately improve HIV outcomes, such as viral suppression and AIDS-related comorbidities. Methods: We recruited English- and Spanish-speaking persons living with HIV?(PLWH) who were ≥19?years of age or older and had initiated ART after January 1, 2006, until saturation was reached (n=28). We excluded patients who had started on ART more than 10 years earlier, in order to ensure responses were relevant to more contemporary ART regimens. We recruited racial/ethnic and sexual minorities, including men who have sex with men and transgender participants, to reflect the current HIV epidemic. Nominal group technique was used to identify and prioritize preferences and concerns. Multi-voting analysis was used to quantify responses from most important (5 points) to least important (1 point). Results: For 28 diverse participants, clinical outcomes (162 points) and quality of life (120 points) were preferred. Hispanic participants were more concerned about accessibility than non-Hispanic (3.8 vs 1.9 average points/participant). Discussion: HIV-infected persons prioritize access, clinical outcomes, and quality of life when considering contemporary ART treatment. Providers, insurers and policy makers should incorporate these preferences when making decisions about ART.
机译：目的：本研究的目的是通过重点研究三个领域来了解患者对现代抗逆转录病毒疗法（ART）的偏好：少数群体患者（种族/族裔和性少数群体），新型单片治疗方案的经验最近十年，以及与ART相关的患者担忧。这样做的理由是，确定最理想的抗逆转录病毒药物特性可以为提供者开处方提供依据，增加以患者为中心的抗逆转录病毒药物的使用，最大限度地提高持久性和抗逆转录病毒依从性，并最终改善艾滋病毒的预后，例如病毒抑制和艾滋病相关合并症。方法：我们招募了年龄在19岁或以上且年龄≥19岁的英语和西班牙语的HIV感染者（PLWH），并于2006年1月1日之后开始抗病毒治疗，直至达到饱和（n = 28）。我们排除了10年前开始使用抗逆转录病毒疗法的患者，以确保其反应与更现代的抗逆转录病毒疗法相关。我们招募了种族/族裔和性少数群体，包括与男性发生性关系的男性和跨性别参与者，以反映当前的艾滋病流行情况。标称组技术被用来识别偏好和关注点并对其进行优先排序。多投票分析用于量化从最重要（5分）到最不重要（1分）的响应。结果：对于28名不同的参与者，临床结局（162分）和生活质量（120分）是首选。与非西班牙裔相比，西班牙裔参与者更关注可及性（每位参与者平均3.8 vs 1.9）。讨论：在考虑当代抗逆转录病毒治疗时，艾滋病毒感染者会优先考虑药物的获取，临床结果和生活质量。提供者，保险公司和政策制定者在做出抗逆转录病毒药物决策时应考虑这些偏好。

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