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首页> 外文期刊>Patient Preference and Adherence >Long term safety, efficacy, and patient acceptability of hyaluronic acid injection in patients with painful osteoarthritis of the knee
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Long term safety, efficacy, and patient acceptability of hyaluronic acid injection in patients with painful osteoarthritis of the knee

机译：透明质酸注射液在膝关节疼痛性骨关节炎患者中的长期安全性，疗效和患者可接受性

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Abstract: The increasing prevalence of painful knee osteoarthritis has created an additional demand for pharmacologic management to prevent or delay surgical management. Viscosupplementation, via intraarticular injection of hyaluronic acid (HA), aims to restore the favorable milieu present in the nonarthritic joint. The safety profile of intraarticular HA injections for painful knee osteoarthritis is well established, with the most common adverse effect being a self-limited reaction at the injection site. Although acceptance of the early literature has been limited by publication bias and poor study quality, more recent and rigorous meta-analysis suggests that intraarticular HA injection is superior to placebo injection for pain relief and matches, if not surpasses, the effect size of other nonoperative treatments, such as nonsteroidal anti-inflammatory medication. Intraarticular HA injection is effective in providing temporary pain relief in patients with painful knee osteoarthritis. Future investigations should focus on optimizing the composition and administration of HA agents to provide prolonged relief of painful osteoarthritis in the knee and other joints.
机译：摘要：疼痛性膝骨关节炎的患病率增加，对预防或延迟外科治疗的药理管理提出了额外的要求。通过关节内注射透明质酸（HA）进行粘液补充旨在恢复非关节炎性关节中存在的良好环境。关节内HA注射治疗疼痛性膝骨关节炎的安全性已得到充分确立，最常见的不良反应是注射部位的自限反应。尽管对早期文献的接受受到出版偏见和研究质量差的限制，但较近期和严格的荟萃分析表明，关节内注射HA优于安慰剂注射可缓解疼痛，并且与其他非手术药物的疗效大小相匹配（如果不能超过）治疗方法，例如非甾体抗炎药。关节内注射HA可有效缓解膝关节骨关节炎患者的暂时性疼痛。未来的研究应集中在优化HA药剂的成分和给药，以长期缓解膝盖和其他关节的疼痛性骨关节炎。

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