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首页> 外文期刊>Pharmacy >Stability of Fentanyl Citrate, Hydromorphone Hydrochloride, Ketamine Hydrochloride, Midazolam, Morphine Sulfate, and Pentobarbital Sodium in Polypropylene Syringes
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Stability of Fentanyl Citrate, Hydromorphone Hydrochloride, Ketamine Hydrochloride, Midazolam, Morphine Sulfate, and Pentobarbital Sodium in Polypropylene Syringes

机译：丙酸芬太尼，盐酸氢吗啡酮，盐酸氯胺酮，咪达唑仑，吗啡硫酸盐和戊巴比妥钠在聚丙烯注射器中的稳定性。

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Purpose: Determine the stability of fentanyl 10 mcg/mL in 0.9% sodium chloride, fentanyl 10 mcg/mL in 5% dextrose, fentanyl 50 mcg/mL, hydromorphone 100 mcg/mL in 0.9% sodium chloride, ketamine 10 mg/mL, midazolam 0.4 mg/mL in 5% dextrose, midazolam 5 mg/mL, morphine 1 mg/mL in 0.9% sodium chloride, morphine 1 mg/mL in 5% dextrose, and pentobarbital 50 mg/mL when stored as single drug entities at room temperature in polypropylene syringes. Methods: Four 5 mL samples of each drug and concentration were prepared in 10 mL polypropylene syringes. The samples were stored at ambient room temperature in a locked cabinet. Triplicate determinations of drug concentration for each sample were performed initially, on day 50 or 51, and on day 100 using high-performance liquid chromatography with diode-array detection. Results: With the exception of the hydromorphone 100 mcg/mL dilution, all compounds were found to contain greater than 95% of their initial concentration remaining at 100 days. Each sample remained clear and colorless when visually inspected.
机译：目的：测定在0.9％氯化钠中的芬太尼10 mcg / mL，在5％葡萄糖中的芬太尼10 mcg / mL，芬太尼50 mcg / mL，在0.9％氯化钠中的氢吗啡酮100 mcg / mL，氯胺酮10 mg / mL的稳定性，分别在5％葡萄糖中的咪达唑仑0.4 mg / mL，5％葡萄糖的咪达唑仑，0.9％氯化钠中的吗啡1 mg / mL，5％葡萄糖中的吗啡1 mg / mL和戊巴比妥50 mg / mL室温下使用聚丙烯注射器。方法：在10 mL聚丙烯注射器中制备每种药物和浓度的4个5 mL样品。将样品在室温下储存在上锁的柜子中。使用高效液相色谱和二极管阵列检测，分别在第50天或第51天和第100天对每个样品进行三重测定。结果：除氢吗啡酮稀释度为100 mcg / mL外，所有化合物在100天时的残留浓度均超过其初始浓度的95％。目视检查时，每个样品均保持透明无色。

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