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Tissue Engineering Bionanocomposites Based on Poly(propylene fumarate)

机译：基于聚富马酸丙二醇酯的组织工程生物纳米复合材料

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Poly(propylene fumarate) (PPF) is a linear and unsaturated copolyester based on fumaric acid that has been widely investigated for tissue engineering applications in recent years due to its tailorable mechanical performance, adjustable biodegradability and exceptional biocompatibility. In order to improve its mechanical properties and spread its range of practical applications, novel approaches need to be developed such as the incorporation of fillers or polymer blending. Thus, PPF-based bionanocomposites reinforced with different amounts of single-walled carbon nanotubes (SWCNT), multi-walled carbon nanotubes (MWCNT), graphene oxide nanoribbons (GONR), graphite oxide nanoplatelets (GONP), polyethylene glycol-functionalized graphene oxide (PEG-GO), polyethylene glycol-grafted boron nitride nanotubes (PEG- g -BNNTs) and hydroxyapatite (HA) nanoparticles were synthesized via sonication and thermal curing, and their morphology, biodegradability, cytotoxicity, thermal, rheological, mechanical and antibacterial properties were investigated. An increase in the level of hydrophilicity, biodegradation rate, stiffness and strength was found upon increasing nanofiller loading. The nanocomposites retained enough rigidity and strength under physiological conditions to provide effective support for bone tissue formation, showed antibacterial activity against Gram-positive and Gram-negative bacteria, and did not induce toxicity on human dermal fibroblasts. These novel biomaterials demonstrate great potential to be used for bone tissue engineering applications.
机译：聚富马酸丙二醇酯（PPF）是一种基于富马酸的线性和不饱和共聚酯，由于其可调节的机械性能，可调节的生物降解性和出色的生物相容性，近年来已在组织工程应用中进行了广泛的研究。为了改善其机械性能并扩展其实际应用范围，需要开发新方法，例如掺入填料或聚合物共混物。因此，用不同数量的单壁碳纳米管（SWCNT），多壁碳纳米管（MWCNT），氧化石墨烯纳米带（GONR），氧化石墨纳米片（GONP），聚乙二醇官能化的氧化石墨烯（PPNF）增强的PPF基生物纳米复合材料（通过超声和​​热固化合成了PEG-GO），聚乙二醇接枝的氮化硼纳米管（PEG-g -BNNTs）和羟基磷灰石（HA）纳米颗粒，它们的形态，生物降解性，细胞毒性，热，流变，机械和抗菌性能均达到了调查。发现随着纳米填料负载的增加，亲水性，生物降解速率，刚度和强度的水平增加。该纳米复合材料在生理条件下保留了足够的刚性和强度，可以为骨组织形成提供有效的支持，对革兰氏阳性和革兰氏阴性细菌显示出抗菌活性，并且对人皮肤成纤维细胞没有毒性。这些新颖的生物材料具有巨大的潜力，可用于骨组织工程应用。

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