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Genes, environment and schizophrenia

机译：基因，环境与精神分裂症

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Background Data from family, twin and adoption studies show over whelming evidence of a substantial genetic component in schizophrenia and although molecular genetic studies have been more difficult to replicate, recent improvements in technology have resulted in the implication of genes at several chromosomal loci. Nevertheless, it remains clear that environmental factors both add to and interact with genetic factors to produce the disorder. Aims To incorporate genetic and environmental risk factors into a neurodevelopmental model in order to conceptualise the liability to schizophrenia. Method A representative selection of the literature related to this issue is reviewed, together with a reformulation of Meehl's term a€? schizotaxiaa€? to describe the liability to the disorder. Results The literature supports a multi-factorial view of the liability to schizophrenia, which includes both genetic and environmental components. Conclusions Schizotaxia provides a useful way to conceptualise both the liability for schizophrenia, and also the development of treatment strategies aimed at the eventual prevention of the illness.
机译：来自家庭，双胞胎和收养研究的背景数据显示出精神分裂症中大量遗传成分的大量证据，尽管分子遗传学研究较难复制，但最近的技术进步已导致基因在多个染色体基因座上的存在。然而，仍然很清楚，环境因素会增加遗传因素并与之相互作用，从而导致疾病。目的将遗传和环境危险因素纳入神经发育模型，以概念化精神分裂症的危害。方法回顾了与该问题相关的代表性文献，并对Meehl的术语a？进行了重新表述。精神分裂症？描述对疾病的责任。结果文献支持对精神分裂症的多因素观点，包括遗传和环境因素。结论精神分裂症为概念化精神分裂症的责任以及开发旨在最终预防该病的治疗策略提供了一种有用的方法。

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