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Stimulant psychosis: systematic review

机译:兴奋性精神病:系统评价

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Background Psychosis associated with stimulant use is an increasing problem, but there is little research evidence about the nature of the problem and its management. Aims To critically review the literature on stimulant psychosis and sensitisation. Method Systematic review of studies that have investigated stimulant use and psychosis in humans. The main outcome measures were increases in psychosis with stimulant use, and differences between stimulant users and non-users. Results Fifty-four studies met the inclusion criteria. Experimental studies show that a single dose of a stimulant drug can produce a brief increase in psychosis ratings (aa€?responsea€?) in 50-70% of participants with schizophrenia and pre-existing acute psychotic symptoms, unaffected by the presence of antipsychotic medication. Those with schizophrenia who do not have acute psychotic symptoms respond, but less frequently (30%). There has been little research into the longer-term effects of use. Conclusions Compliance with antipsychotic medication by someone with schizophrenia will not prevent a relapse or worsening of psychotic symptoms if stimulants are used. Low-dose antipsychotic treatment may be beneficial in stimulant users, to prevent sensitisation.
机译:背景技术与兴奋剂使用相关的精神病是一个日益严重的问题,但是关于该问题的性质及其管理的研究证据很少。目的严格审查有关兴奋性精神病和致敏作用的文献。方法对研究人类兴奋剂使用和精神病的研究进行系统回顾。主要结果指标是使用兴奋剂导致精神病增加,以及兴奋剂使用者和非使用者之间的差异。结果54项研究符合纳入标准。实验研究表明,单剂兴奋剂可在50-70%的精神分裂症和先前存在的急性精神病症状的受试者中引起精神病等级的短暂提高(反应性),而不受抗精神病药的影响药物。没有急性精神病症状的精神分裂症患者有反应,但频率较低(30%)。很少有关于使用的长期影响的研究。结论精神分裂症患者服用抗精神病药物并不能预防精神病症状的复发或加重。小剂量抗精神病药治疗可能对兴奋剂使用者有益,可防止过敏。

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