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Cardiff Depression Study

机译:卡迪夫抑郁症研究

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Background An excess of both depression and undesirable life events in first-degree relatives of probands with depression as compared with controls has been reported. This association may have reflected a familial factor in common. Aims To examine the familiality of life events and depression and whether there may be a common familial factor influencing vulnerability to depression and the experiencing of life events. Method In a sib-pair design, 108 probands with depression and their siblings were compared with 105 healthy controls and their siblings for psychopathology and life events. Results The lifetime relative risk of depressive disorder in the siblings of depressed subjects as compared with siblings of controls was 9.74, although these groups did not differ in the life events measures. Several categories of events showed significant sibling correlations, but this was due to the same event affecting both members of the pair. Conclusions Although depressive disorder was strongly familial, the familial effects on life events were largely explained by shared experiences. There was no evidence for a common factor influencing both depression and life events.
机译:背景技术与对照组相比,患有抑郁症的先证者的一级亲属中抑郁症和不良生活事件过多。这种关联可能反映了共同的家族因素。目的研究生活事件和抑郁症的家族性,以及是否存在影响抑郁症和生活事件经历的常见家族性因素。方法在同胞对设计中,将108名抑郁症及其兄弟姐妹的先证者与105名健康对照及其兄弟姐妹的心理病理学和生活事件进行了比较。结果与对照组相比,抑郁受试者的兄弟姐妹终生相对抑郁风险为9.74,尽管这些组的生活事件量度没有差异。几类事件显示出显着的同级关联性,但这是由于同一事件影响到该对的两个成员。结论尽管抑郁症是强烈的家族性疾病,但家族性疾病对生活事件的影响在很大程度上是通过共同的经历来解释的。没有证据表明影响抑郁症和生活事件的共同因素。

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