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首页> 外文期刊>The Internet Journal of Tropical Medicine >The Spectrum Of Childhood Meningitis In Barbados: A Population Based Study
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The Spectrum Of Childhood Meningitis In Barbados: A Population Based Study

机译：巴巴多斯儿童脑膜炎的范围：基于人群的研究

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Objectives: To describe the epidemiologic characteristics of meningitis in children during a 12 year period, from 1994 to 2005, in Barbados, with particular emphasis on the trends in incidence and age distribution.Methods: This is a retrospective population based study of all childhood meningitis over a 12 years period. A chart review was conducted of all patients outside of the neonatal age group hospitalized at the Queen Elizabeth Hospital of Barbados with a diagnosis of meningitis from January 1994 to November 2005. Results: There were 327 cases of meningitis, 235 (71%) cases were categorized as aseptic meningitis and 92 (29%) were categorized as bacterial meningitis. The median age of children with aseptic meningitis was 3 years (Range 2 months - 15 years) and the median age for patients with bacterial meningitis was 18.0 months and ranged in age from 1 months to 15 years (P < 0.05). Fifty nine percent of the cases of aseptic meningitis and 50% of the cases of bacterial meningitis occurred in boys. The annual incidence of pyogenic meningitis has varied narrowly in between 10 to 20 per 100, 000 under 16 populations, with a decline to less than 5 in 2005. The annual incidence rate of aseptic meningitis showed two epidemics with the rate peaking above 40 cases per 100, 000 under 16 population in 1997 and 2001. Through out the study period, a little over half of all meningitis in < 5 years children was pyogenic without any significant trend.Conclusions: The incidence of pyogenic meningitis in Barbados has shown a modest decline since early 2000. Aseptic meningitis is as common as pyogenic meningitis and shows seasonality during the year with epidemics every few years. Introduction The epidemiology of childhood meningitis has been constantly changing over the past two decades (1). With the advent of conjugate hemophilus influenza vaccine both the incidence of over all bacterial meningitis and the incidence of meninigitis due to hemophilus influenza have declined (1, 2). Also there have been changes in the etiology and incidence of aseptic meningitis (3). Several studies have characterized the epidemiology of the Bacterial meningitis in the English speaking Caribbean including Barbados in the eighties and early nineties (4,5,6). Since early two thousand many Caribbean countries including Barbados have been using conjugated hemophilus influenza vaccine to routinely immunize all the children. However, there is no recent published report on the pattern of meningitis from the English speaking Caribbean. In this study, we describe the epidemiology of the meningitis in children during a 12 year period, from 1994 to 2005, in Barbados, with particular emphasis on the trends in incidence, age distribution and etiology of pyogenic meningitis in this country. Methods This is a retrospective population based study of all childhood (all children outside the neonatal period and aged U test. For categorical variables, the Pearson χ 2 test was used to assess between group differences. Results There were 327 cases of meningitis during the twelve years study period from 1994 through 2005, in children less the 16 years of age. Two hundred thirty-five cases were categorized as aseptic meningitis and 92 were categorized as bacterial meningitis. These patients with the diagnosis of meningitis including both the pyogenic meningitis and the aseptic meningitis ranged in age from 1 month to 15 years; the median age for patients was 3 years. Over all 56% of all the cases of meningitis occurred among boys and 44% among girls. The median age of children with aseptic meningitis was 3 years (Range 2 months – 15 years) and the median age for patients with bacterial meningitis was 18.0 months and ranged in age from 1 months to 15 years(P < 0.05). Fifty nine percent of all the cases of aseptic meningitis and 50% of the cases of bacterial meningitis occurred in boys (P = NS). All but one cases occurred among children of Afro-Caribbean decent. A single case of men
机译：目的：描述1994年至2005年在巴巴多斯为期12年的儿童脑膜炎的流行病学特征，特别着重于发病率和年龄分布趋势。方法：这是一项基于人群的回顾性研究，涉及所有儿童期脑膜炎。在12年的时间里。从1994年1月至2005年11月，对在巴巴多斯伊丽莎白女王医院住院的新生儿年龄组以外的所有患者进行了病历审查。结果：327例脑膜炎，其中235例（71％）为脑膜炎。被归类为无菌性脑膜炎，有92个（29％）被归类为细菌性脑膜炎。无菌性脑膜炎患儿的中位年龄为3岁（范围2个月至15岁），细菌性脑膜炎患儿的中位年龄为18.0个月，范围为1个月至15岁（P <0.05）。无菌性脑膜炎病例中有59％，细菌性脑膜炎病例中有50％发生在男孩中。化脓性脑膜炎的年发病率狭窄，在16个人口中每10万人中有10至20人之间，在2005年下降到不足5个。无菌性脑膜炎的年发病率显示出两次流行，最高时每人40例以上在1997年和2001年，有100,000名16岁以下的人口在整个研究期间，小于5岁的儿童中所有脑膜炎的化脓性疾病略有增加，而没有任何明显的趋势。结论：巴巴多斯化脓性脑膜炎的发病率有所下降自2000年初以来。无菌性脑膜炎与化脓性脑膜炎一样常见，并且每年呈季节性变化，每隔几年流行一次。简介在过去的二十年中，儿童脑膜炎的流行病学一直在不断变化（1）。随着共轭血友病流感疫苗的出现，所有细菌性脑膜炎的发生率和因血友病流感引起的脑膜炎的发生率均下降了（1、2）。无菌性脑膜炎的病因和发病率也有所变化（3）。几项研究已表征了英语加勒比海地区细菌性脑膜炎的流行病学特征，包括八十年代和九十年代初的巴巴多斯（4,5,6）。自2000年初以来，包括巴巴多斯在内的许多加勒比海国家一直在使用共轭血友病流感疫苗常规免疫所有儿童。但是，最近没有发表过关于加勒比海英语的关于脑膜炎的报道。在这项研究中，我们描述了1994年至2005年在巴巴多斯为期12年的儿童脑膜炎的流行病学，特别着重于该国化脓性脑膜炎的发病率，年龄分布和病因学趋势。方法：这是一项回顾性的基于人群的研究，研究了所有儿童期（所有新生儿期和年龄大于U检验的儿童。对于分类变量，使用Pearsonχ2检验评估组间差异。结果在十二个月中有327例脑膜炎病例从1994年至2005年，我们对16岁以下儿童进行了3年的研究，其中235例为无菌性脑膜炎，92例为细菌性脑膜炎，这些诊断为脑膜炎的患者包括化脓性脑膜炎和脑膜炎。无菌性脑膜炎的年龄范围为1个月至15岁;患者的中位年龄为3岁;在所有脑膜炎病例中，全部56％发生在男孩中，44％发生在女孩中，无菌性脑膜炎患儿的中位年龄为3岁。年（范围2个月至15岁），细菌性脑膜炎患者的中位年龄为18.0个月，年龄范围为1个月至15岁（P <0.05）。所有无菌性脑膜炎病例和50％细菌性脑膜炎病例均发生在男孩中（P = NS）。除一例外，其余病例均发生在非洲加勒比体面的儿童中。一箱男人

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