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首页> 外文期刊>The Korean Journal of Physiology & Pharmacology >Foeniculum vulgare Mill. Protects against Lipopolysaccharide-induced Acute Lung Injury in Mice through ERK-dependent NF-κB Activation
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Foeniculum vulgare Mill. Protects against Lipopolysaccharide-induced Acute Lung Injury in Mice through ERK-dependent NF-κB Activation

机译：普通小麦。通过ERK依赖性NF-κB活化保护脂多糖诱导的小鼠急性肺损伤

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Foeniculum vulgare Mill. (fennel) is used to flavor food, in cosmetics, as an antioxidant, and to treat microbial, diabetic and common inflammation. No study to date, however, has assessed the anti-inflammatory effects of fennel in experimental models of inflammation. The aims of this study were to investigate the anti-inflammatory effects of fennel in model of lipopolysaccharide (LPS)-induced acute lung injury. Mice were randomly assigned to seven groups (n=7~10). In five groups, the mice were intraperitoneally injected with 1% Tween 80-saline (vehicle), fennel (125, 250, 500μl/kg), or dexamethasone (1 mg/kg), followed 1 h later by intratracheal instillation of LPS (1.5 mg/kg). In two groups, the mice were intraperitoneally injected with vehicle or fennel (250μl/kg), followed 1 h later by intratracheal instillation of sterile saline. Mice were sacrificed 4 h later, and bronchoalveolar lavage fluid (BALF) and lung tissues were obtained. Fennel significantly and dose-dependently reduced LDH activity and immune cell numbers in LPS treated mice. In addition fennel effectively suppressed the LPS-induced increases in the production of the inflammatory cytokines interleukin-6 and tumor necrosis factor-alpha, with 500μl/kg fennel showing maximal reduction. Fennel also significantly and dose-dependently reduced the activity of the proinflammatory mediator matrix metalloproteinase 9 and the immune modulator nitric oxide (NO). Assessments of the involvement of the MAPK signaling pathway showed that fennel significantly decreased the LPS-induced phosphorylation of ERK. Fennel effectively blocked the inflammatory processes induced by LPS, by regulating pro-inflammatory cytokine production, transcription factors, and NO.
机译：普通小麦。 （茴香）用于在化妆品中为食品增香，作为抗氧化剂，并用于治疗微生物，糖尿病和常见的炎症。但是，迄今为止，尚无研究评估炎症实验模型中茴香的抗炎作用。这项研究的目的是调查茴香在脂多糖（LPS）诱导的急性肺损伤模型中的抗炎作用。将小鼠随机分为7组（n = 7〜10）。在五组中，给小鼠腹膜内注射1％Tween 80盐水（车辆），茴香（125、250、500μl / kg）或地塞米松（1 mg / kg），然后在1小时后气管内滴注LPS（ 1.5 mg / kg）。在两组中，向小鼠腹膜内注射媒介物或茴香（250μl/ kg），然后在1小时后通过气管内滴注无菌盐水。 4小时后处死小鼠，获得支气管肺泡灌洗液（BALF）和肺组织。在LPS处理的小鼠中，茴香显着且剂量依赖性地降低了LDH活性和免疫细胞数量。此外，茴香有效地抑制了LPS诱导的炎性细胞因子白细胞介素6和肿瘤坏死因子-α的产生增加，其中500μl/ kg的茴香表现出最大的减少。茴香还显着且剂量依赖性地降低了促炎性介质金属蛋白酶9和免疫调节剂一氧化氮（NO）的活性。 MAPK信号通路参与的评估表明，茴香显着降低了LPS诱导的ERK磷酸化。茴香通过调节促炎细胞因子的产生，转录因子和NO，有效地阻断了LPS诱导的炎症过程。

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