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首页> 外文期刊>The Open Anesthesia Journal >Analgesic Effect of Nebulized Versus Intravenous Fentanyl for Pain Relief of Limb Fracture: A Double-Blind Clinical Trial
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Analgesic Effect of Nebulized Versus Intravenous Fentanyl for Pain Relief of Limb Fracture: A Double-Blind Clinical Trial

机译：雾化芬太尼与静脉芬太尼对肢体骨折疼痛的镇痛作用：双盲临床试验

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Background:More than half of the patients attending emergency centers need analgesics. Injectable analgesics are currently the most common pain control strategy, but entail complications. Fentanyl is one of the most commonly used pain-relief opiates available in various forms.Objective:The present study aims to compare analgesic effects of nebulized against intravenous fentanyl for controlling pain due to limb fracture.Method:The present double-blind clinical trial recruited 213 patients presenting with fractured limbs to emergency departments. The first group of patients received 1 micg/kg of intravenous fentanyl citrate from a solution of 50 micg/ml and 5 ml of normal saline in nebulized form (group A), and the second group intravenously received 5 ml of normal saline and 4 micg/kg of 50 micg/ml solution of fentanyl citrate in nebulized form, whose volume reached 5 ml with the addition of normal saline (group B). Then, pain level was frequently measured and compared in the two groups for 20 minutes.Results:The results obtained showed reduced pain level in both the groups. However, point-by-point comparison of pain in the two groups revealed significantly greater pain reduction in intravenous fentanyl group (P<0.001). The need for adjuvant pain relief medication was 8.3% in intravenous fentanyl group and 24% in nebulized fentanyl group, with a significant difference between the two groups (P=0.002).Conclusion:According to the results, although nebulized fentanyl is effective in controlling pain due to limb fracture, it was less effective than intravenous type, and unable to control pain in many cases.
机译：背景：到急诊中心就诊的患者中有一半以上需要镇痛药。注射镇痛药是目前最常见的止痛策略，但需要并发症。芬太尼是最常用的各种形式的止痛鸦片之一。目的：本研究旨在比较雾化与静脉注射芬太尼的镇痛效果，以控制肢体骨折引起的疼痛。方法：本双盲临床试验213名四肢骨折的患者前往急诊科。第一组患者从50 micg / ml溶液和5 ml雾化形式的生理盐水中接受1 micg / kg静脉注射柠檬酸芬太尼（A组），第二组患者静脉注射5 ml生理盐水和4 micg静脉注射/ kg雾化形式的柠檬酸芬太尼50 mcg / ml溶液，加入生理盐水后其体积达到5 ml（B组）。然后，频繁测量疼痛水平并在两组中进行20分钟的比较。结果：获得的结果表明两组疼痛水平均降低。然而，两组疼痛的逐点比较显示，静脉芬太尼组的疼痛减轻明显更大（P <0.001）。静脉芬太尼组需要辅助止痛药，雾化芬太尼组需要24％，两组之间有显着差异（P = 0.002）。结论：根据结果，尽管雾化芬太尼可以有效地控制由于肢体骨折引起的疼痛，其效果不如静脉注射型，并且在许多情况下无法控制疼痛。

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