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首页> 外文期刊>The Open Neuroendocrinology Journal >Effects of Incentives and Genetics on Food Choices and WeightPhenotypes in the Neuroendocrine Gene Tubby Mutant Mice
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Effects of Incentives and Genetics on Food Choices and WeightPhenotypes in the Neuroendocrine Gene Tubby Mutant Mice

机译：动机和遗传学对神经内分泌基因成簇突变小鼠食物选择和体重表型的影响

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Food intake and obesity related phenotypes are greatly affected by economic factors and yet very little isknown about the interaction of economic factors, genetics, behavior, and obesity phenotypes. Recent human populationresearch suggests that a decreasing price of high fat food relative to low fat food has contributed to the current obesityepidemic in humans. The two key elements in this argument are choice and costs. We incorporate these key elements in aclosed economy mouse model to study the interactions of economics, genetics, and obesity related phenotypes, usingnormal mice, and mice with a mutation in the hypothalamus-expressed Tub gene, which has a phenotype of adult onsetobesity. Results for both genotypes indicate that as the price of the high fat food falls, consumption of that food increasesand consumption of the low fat food declines, but not enough to offset the increase in high fat food so total intake andweight increases, with no statistically-significant differences between genotypes. These results are in contrast to previousliterature based on an ad lib, no choice food setting. In addition, in our closed economy model, the Tub mutant showed anumerical and statistically significant increase in body fat percentage and glucose intolerance, whereas these increaseswere only numerical for the normal mice. Both genotypes showed numerical but statistically insignificant increases inleptin and ghrelin levels. These results show that accounting for choice in neuroeconomic studies is important tounderstanding the complex regulation of intake, body weight and other related phenotypes.
机译：与食物摄入和肥胖有关的表型受经济因素的影响很大，但对经济因素，遗传，行为和肥胖表型之间相互作用的了解却很少。最近的人口研究表明，高脂食品相对于低脂食品的价格下降导致了目前的人类肥胖症流行病。该论点的两个关键要素是选择和成本。我们将这些关键要素纳入封闭型经济小鼠模型中，以研究经济学，遗传学和肥胖相关表型的相互作用，使用正常小鼠以及下丘脑表达的Tub基因突变的小鼠，该基因具有成年成年肥胖症的表型。两种基因型的结果均表明，随着高脂食品价格的下跌，该食品的消费量增加而该低脂食品的消费量下降，但不足以抵消高脂食品的增加，因此总摄入量和体重增加，而在统计上没有-基因型之间的显着差异。这些结果与以前基于即席自由选择食物设置的文献形成对照。此外，在我们的封闭经济模型中，Tub突变体显示体脂百分比和葡萄糖耐量异常增加，且统计学上显着增加，而这些增加只是正常小鼠的数值。两种基因型均显示出leptin和ghrelin水平的升高，但在统计学上无统计学意义。这些结果表明，神经经济学研究中的选择对于理解摄入量，体重和其他相关表型的复杂调节很重要。

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