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首页> 外文期刊>Hepatology international >Clinical utility of prothrombin induced by vitamin K absence in the detection of hepatocellular carcinoma in Indian population
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Clinical utility of prothrombin induced by vitamin K absence in the detection of hepatocellular carcinoma in Indian population

机译：维生素K缺乏引起的凝血酶原在印度人群肝细胞癌检测中的临床应用

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BackgroundAlpha-fetoprotein (AFP) is a well known widely used biomarker for the detection of hepatocellular carcinoma (HCC); however, it suffers from a low sensitivity and specificity. Protein or prothrombin induced by vitamin K absence or antagonist II (PIVKA-II) is another tumor marker elevated in HCC but not extensively used.AimEvaluation of PIVKA-II and AFP in diagnosing HCC in India.Patients and methodsThe study group consisted of 70 consecutive HCC patients, 38 patients with cirrhosis, 30 patients with chronic hepatitis, and 30 normal healthy subjects. All patients were evaluated for PIVKA-II and AFP levels by ELISA.ResultThe mean plasma concentration of PIVKA-II in HCC, cirrhotic, chronic hepatitis patients and healthy controls was 101.07?±?78.30?ng/ml, 2.45?±?4.25?ng/ml, 1.50?±?0.98?ng/ml and 0.79?±?0.75?ng/ml, respectively. Receiver operating characteristic (ROC) curve was plotted for PIVKA-II and AFP. At a cutoff level of 9.2?ng/ml for PIVKA-II a sensitivity of 80% and a specificity of 92.1% was found, whereas AFP at a cutoff level of 13.02?ng/ml showed 72.9% sensitivity and 65.8% specificity. No significant relationship of plasma levels of PIVKA-II was observed in HCC with HBsAg/antiHCV positivity and associated portal vein thrombosis, but a positive correlation was seen with the tumor size (P?=?0.001). However, no such significant association was found with AFP.ConclusionPIVKA-II was more sensitive and specific than AFP for diagnosing HCC in the Indian population.
机译：背景甲胎蛋白（AFP）是众所周知的用于检测肝细胞癌（HCC）的生物标志物;但是，其敏感性和特异性低。缺乏维生素K或拮抗剂II（PIVKA-II）诱导的蛋白质或凝血酶原是HCC中升高但又未广泛使用的另一种肿瘤标志物.PIVKA-II和AFP在印度诊断HCC中的目标评估。患者和方法研究组由70个连续的研究组成HCC患者，38例肝硬化患者，30例慢性肝炎患者和30名正常健康受试者。结果：HCC，肝硬化，慢性肝炎和健康对照者的PIVKA-II平均血浆浓度为101.07±±78.30？ng / ml，2.45±±4.25?。 ng / ml，1.50±±0.98ng / ml和0.79±±0.75ng / ml。绘制了PIVKA-II和AFP的接收器工作特性（ROC）曲线。对于PIVKA-II，在9.2？ng / ml的临界值水平时，发现灵敏度为80％，特异性为92.1％，而在13.02？ng / ml的临界值时，AFP显示72.9％的灵敏度和65.8％的特异性。在肝癌中未观察到血浆PIVKA-II水平与HBsAg / antiHCV阳性和相关的门静脉血栓形成有显着相关性，但与肿瘤大小呈正相关（P = 0.001）。然而，未发现与AFP有这种显着相关性。结论PIVKA-II在诊断印度人HCC方面比AFP更为敏感和特异性。

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