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首页> 外文期刊>Hepatology international >Clinical utility of prothrombin induced by vitamin K absence in the detection of hepatocellular carcinoma in Indian population.
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Clinical utility of prothrombin induced by vitamin K absence in the detection of hepatocellular carcinoma in Indian population.

机译：维生素K缺乏引起的凝血酶原在印度人群肝细胞癌检测中的临床应用。

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BACKGROUND: Alpha-fetoprotein (AFP) is a well known widely used biomarker for the detection of hepatocellular carcinoma (HCC); however, it suffers from a low sensitivity and specificity. Protein or prothrombin induced by vitamin K absence or antagonist II (PIVKA-II) is another tumor marker elevated in HCC but not extensively used. AIM: Evaluation of PIVKA-II and AFP in diagnosing HCC in India. PATIENTS AND METHODS: The study group consisted of 70 consecutive HCC patients, 38 patients with cirrhosis, 30 patients with chronic hepatitis, and 30 normal healthy subjects. All patients were evaluated for PIVKA-II and AFP levels by ELISA. RESULT: The mean plasma concentration of PIVKA-II in HCC, cirrhotic, chronic hepatitis patients and healthy controls was 101.07 +/- 78.30 ng/ml, 2.45 +/- 4.25 ng/ml, 1.50 +/- 0.98 ng/ml and 0.79 +/- 0.75 ng/ml, respectively. Receiver operating characteristic (ROC) curve was plotted for PIVKA-II and AFP. At a cutoff level of 9.2 ng/ml for PIVKA-II a sensitivity of 80% and a specificity of 92.1% was found, whereas AFP at a cutoff level of 13.02 ng/ml showed 72.9% sensitivity and 65.8% specificity. No significant relationship of plasma levels of PIVKA-II was observed in HCC with HBsAg/antiHCV positivity and associated portal vein thrombosis, but a positive correlation was seen with the tumor size (P = 0.001). However, no such significant association was found with AFP. CONCLUSION: PIVKA-II was more sensitive and specific than AFP for diagnosing HCC in the Indian population.
机译：背景：甲胎蛋白（AFP）是众所周知的用于检测肝细胞癌（HCC）的生物标志物。但是，其敏感性和特异性低。缺乏维生素K或拮抗剂II（PIVKA-II）诱导的蛋白质或凝血酶原是HCC中升高的另一种肿瘤标志物，但并未广泛使用。目的：评估PIVKA-II和AFP在印度HCC的诊断中。患者与方法：研究组由70例连续的HCC患者，38例肝硬化患者，30例慢性肝炎患者和30例正常健康受试者组成。通过ELISA评估所有患者的PIVKA-II和AFP水平。结果：在肝癌，肝硬化，慢性肝炎患者和健康对照组中，PIVKA-II的平均血浆浓度为101.07 +/- 78.30 ng / ml，2.45 +/- 4.25 ng / ml，1.50 +/- 0.98 ng / ml和0.79分别为+/- 0.75 ng / ml。绘制了PIVKA-II和AFP的接收器工作特性（ROC）曲线。对于PIVKA-II，在9.2 ng / ml的截断水平下，发现灵敏度为80％，特异性为92.1％，而在13.02 ng / ml的截断水平下，AFP显示了72.9％的灵敏度和65.8％的特异性。在肝癌中，未观察到血浆PIVKA-II水平与HBsAg / antiHCV阳性和相关的门静脉血栓形成有显着相关性，但与肿瘤大小呈正相关（P = 0.001）。但是，没有发现与AFP有这种显着关联。结论：PIVKA-II比AFP对印度人群HCC的诊断更为敏感和特异性。

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