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首页> 外文期刊>Hong Kong Journal of Paediatrics >Intracranial Haemorrhage Due to Late-Onset Vitamin K Deficiency
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Intracranial Haemorrhage Due to Late-Onset Vitamin K Deficiency

机译：迟发性维生素K缺乏症引起的颅内出血

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Objective: Deficiency of vitamin K predisposes to bleeding and it can be divided into early, classical, or late vitamin K deficiency bleeding (VKDB) according to their onset. Late VKDB occurs after 7th day of life at neonatal period and is associated with intracranial bleeding, serious neurological sequels and death. This retrospective study reviewed the clinical presentations, demographic features and radiological findings of infants with intracranial haemorrhage due to late-onset VKDB. Materials and methods: We identified 26 cases of late VKDB admitted to our hospital from February 1992 to November 2006. Cranial computerised tomography was performed in all patients at diagnosis and at subsequent evaluation. Results: Sixteen of twenty-six patients with late VKDB (61.5%) had intracranial haemorrhage (ICH). The mean age of these 16 patients with ICH was 1.6±0.7 months. All of them were on breastfeeding. Eighteen of them received one mg of vitamin K intramuscularly (IM) shortly after birth. None of them received any other medication. The most common sign and symptom of patients with ICH was bulging fontanel (69%). The most common bleeding site as parenchymal (n=7, 43.7%). The mortality rate was 44% among patients with ICH. Conclusion: For neonates on strict breast-feeding, despite some with vitamin K prophylaxis, some patients still may suffer from intracranial and extracranial bleeding due to vitamin K deficiency. Therefore, additional IM dose of vitamin K may be needed. However, further evidence from larger prospective study is needed to verify this observation.
机译：目的：维生素K缺乏易导致出血，根据发病情况可分为早期，经典或晚期维生素K缺乏性出血（VKDB）。晚期VKDB发生在新生儿生命的第7天后，并与颅内出血，严重的神经后遗症和死亡有关。这项回顾性研究回顾了因迟发性VKDB导致颅内出血的婴儿的临床表现，人口统计学特征和影像学发现。材料和方法：我们鉴定了1992年2月至2006年11月间入院的26例晚期VKDB患者。在诊断和随后的评估中对所有患者均进行了颅脑计算机断层扫描。结果：26例晚期VKDB患者中有16例（61.5％）出现颅内出血（ICH）。这16例ICH患者的平均年龄为1.6±0.7个月。他们都在母乳喂养。其中有18个人在出生后不久就通过肌肉注射（IM）1毫克维生素K。他们都没有接受其他药物治疗。 ICH患者最常见的体征和症状是font门膨出（69％）。最常见的出血部位是实质性出血（n = 7，43.7％）。 ICH患者的死亡率为44％。结论：对于严格母乳喂养的新生儿，尽管有人预防了维生素K，但由于维生素K缺乏，一些患者仍可能遭受颅内和颅外出血。因此，可能需要额外的IM剂量的维生素K。但是，需要来自更大规模的前瞻性研究的进一步证据来验证这一观察结果。

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