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FixPred: a resource for correction of erroneous protein sequences

机译:FixPred:纠正错误蛋白质序列的资源

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Protein databases are heavily contaminated with erroneous (mispredicted, abnormal and incomplete) sequences and these erroneous data significantly distort the conclusions drawn from genome-scale protein sequence analyses. In our earlier work we described the MisPred resource that serves to identify erroneous sequences; here we present the FixPred computational pipeline that automatically corrects sequences identified by MisPred as erroneous. The current version of the associated FixPred database contains corrected UniProtKB/Swiss-Prot and NCBI/RefSeq sequences from Homo sapiens, Mus musculus, Rattus norvegicus, Monodelphis domestica, Gallus gallus, Xenopus tropicalis, Danio rerio, Fugu rubripes, Ciona intestinalis, Branchostoma floridae, Drosophila melanogaster and Caenorhabditis elegans; future releases of the FixPred database will include corrected sequences of additional Metazoan species. The FixPred computational pipeline and database (http://www.fixpred.com) are easily accessible through a simple web interface coupled to a powerful query engine and a standard web service. The content is completely or partially downloadable in a variety of formats. Database URL: http://www.fixpred.com
机译:蛋白质数据库被错误的(错误预测,异常和不完整)序列严重污染,这些错误的数据大大扭曲了从基因组规模的蛋白质序列分析得出的结论。在我们的早期工作中,我们描述了MisPred资源,该资源用于识别错误的序列。在这里,我们介绍了FixPred计算管道,该管道可自动更正MisPred识别为错误的序列。关联的FixPred数据库的当前版本包含来自智人,小家鼠,褐家鼠,家蝇,家蝇,鸡爪蟾,热带达尼奥,达尼奥里奥,河豚草,小肠菜,肠小肠,佛罗里达小枝的校正后的UniProtKB / Swiss-Prot和NCBI / RefSeq序列,果蝇和秀丽隐杆线虫; FixPred数据库的未来版本将包括其他后生动物物种的更正序列。 FixPred计算管道和数据库(http://www.fixpred.com)可以通过简单的Web界面轻松访问,该界面与功能强大的查询引擎和标准Web服务耦合。内容可以全部或部分以各种格式下载。数据库URL:http://www.fixpred.com

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