Microwave assisted synthesis of N-substituted Pyrimidines Using AlCl3 as catalyst and their antimicrobial Activities

Mukesh M. Chavda; Manish J. Solanki; Jasmin J.Solnki Chetna M. Rajyguru; Jatin M. Upadhyay

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Microwave assisted synthesis of N-substituted Pyrimidines Using AlCl3 as catalyst and their antimicrobial Activities

机译：以AlCl3为催化剂的微波辅助合成N-取代的嘧啶及其抗菌活性

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The three component condensation of an aldehyde, Substituted urea and 3-oxobutanamide in presence of catalytic amount of AlCl3 is disclosed for the synthesis of pyrimidine under solvent free microwave irradiation conditions. High yields are achieved even 1 g scale, while reaction times are considerably shortened compare to conventional method The antimicrobial activities of the pyrimidines (1a-t) are compared with those of known chosen standard drugs, viz. ampicillin, chloramphenicol, ciprofloxacin, norfloxacin and griseofulvin.

机译：公开了在催化量的AlCl 3存在下，醛，取代的脲和3-氧代丁酰胺的三组分缩合，用于在无溶剂微波辐射条件下合成嘧啶。与传统方法相比，即使1 g规模也可实现高收率，同时反应时间大大缩短。嘧啶（1a-t）的抗菌活性与已知的选定标准药物的抗菌活性进行了比较，即。氨苄西林，氯霉素，环丙沙星，诺氟沙星和灰黄霉素。

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《Der Pharma Chemica: journal for medicinal chemistry, pharmaceutical chemistry and computational chemistry》 |2010年第4期|共8页
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Mukesh M. Chavda; Manish J. Solanki; Jasmin J.Solnki Chetna M. Rajyguru; Jatin M. Upadhyay;
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2. Microwave assisted synthesis and antimicrobial activity of some novel pyrimidine derivatives [J] . Vaghasia S.J., Shah V.H. Journal of the Serbian Chemical Society . 2007,第2期

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3. Microwave assisted facile synthesis of amino pyrimidines bearing benzofuran and investigation of their antimicrobial activity [J] . D B Aruna Kumar, G K Prakash, M N Kumaraswamy Indian Journal of Chemistry, Section B. Organic Including Medicinal . 2006,第7期

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4. Microwave-Assisted Synthesis of Pyrimidines and 1,2-Dihydro-N-Aryl(Alkyl)-4,6-Dimethyl Pyrimidines [C] . (missing) International symposium on green chemistry in China . 2002

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Microwave assisted synthesis of N-substituted Pyrimidines Using AlCl3 as catalyst and their antimicrobial Activities

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