• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Der Pharma Chemica: journal for medicinal chemistry, pharmaceutical chemistry and computational chemistry >Study of synthesis of novel N,2-diphenylquinazolin-4-amine derivatives as an anti-inflammatory and analgesic agent
【24h】

Study of synthesis of novel N,2-diphenylquinazolin-4-amine derivatives as an anti-inflammatory and analgesic agent

机译：新型N，2-二苯基喹唑啉-4-胺衍生物作为消炎镇痛药的合成研究

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

A series of substituted N,2-diphenylquinazolin-4-amines were synthesized by cyclization of methyl anthranilate and various substituted benzamide giving corresponding 2-phenylquinazolinone followed by replacement of ketonic oxygen with various aryl amino group via chlorination gateway to afford title compounds. The homogeneity and purity of compound was ascertained by Physical constant determination and chromatographic methods. The structure of the synthesized derivative was further confirmed by spectral (FTIR, NMR, MS) and elemental (C, H, N) analysis. These synthesized compounds were screened for anti-inflammatory and analgesic activities using, Rat paw edema method and Hot plate method respectively. All compounds showed average to better activity when compared with Diclofenac and Tramadol respectively as standard.
机译：通过邻氨基苯甲酸甲酯和各种取代的苯甲酰胺的环化反应，得到相应的2-苯基喹唑啉酮，然后通过氯化途径用各种芳基氨基取代酮氧，制得一系列取代的N，2-二苯基喹唑啉-4-胺。通过物理常数测定和色谱法确定化合物的均质性和纯度。通过光谱（FTIR，NMR，MS）和元素（C，H，N）分析进一步证实了合成衍生物的结构。分别使用大鼠爪水肿法和热板法筛选这些合成的化合物的抗炎和镇痛活性。与分别以双氯芬酸和曲马多为标准品相比，所有化合物均显示出平均至更好的活性。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号