Synthesis, characterization and fungicidal activity of N-(5-oxo-3,7-diaryl-6,7-dihydro-5H-thiazolo [3,2,a] pyrimidin-6-yl) benzamide derivatives

Shradha P; Prateek P; Jagdamba Singh

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Synthesis, characterization and fungicidal activity of N-(5-oxo-3,7-diaryl-6,7-dihydro-5H-thiazolo [3,2,a] pyrimidin-6-yl) benzamide derivatives

机译：N-（5-氧代-3,7-二芳基-6,7-二氢-5H-噻唑洛[3,2，a]嘧啶-6-基）苯甲酰胺衍生物的合成，表征和杀真菌活性

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2-Amino-4-aryl thiazoles and their derivatives have long been used as precursors for the synthesis of biologically active molecules. Therefore new antifungal compounds IV(a-e) have been synthesized incorporating 2-Amino-4-aryl thiazole. The title compounds were synthesized through isolable intermediates. All the synthesized compounds have been characterized by their elemental analysis, 1HNMR and Mass spectra. The synthesized compounds were evaluated in vitro for their antifungal activity against the test fungi by poisoned food technique; at 1000, 100 and 10 ppm using Czapek's agar medium. A standard commercial fungicide Dithane M-45 was also tested under similar conditions for comparison. It was found that all the compounds were antifungal active but amongst them IVd displayed fungicidal action comparable with that of commercial fungicide Dithane M-45.

机译：2-氨基-4-芳基噻唑及其衍生物长期以来一直用作合成生物活性分子的前体。因此，已经合成了包含2-氨基-4-芳基噻唑的新的抗真菌化合物IV（a-e）。通过可分离的中间体合成标题化合物。所有合成的化合物均已通过元素分析，1 HNMR和质谱进行了表征。用有毒食品技术对合成的化合物在体外对测试真菌的抗真菌活性进行了评估。使用Czapek琼脂培养基分别以1000、100和10 ppm的浓度还在类似条件下测试了标准的商业杀菌剂Dithane M-45进行比较。发现所有化合物均具有抗真菌活性，但其中IVd的杀真菌作用与商业杀真菌剂Dithane M-45相当。

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《Der Pharma Chemica: journal for medicinal chemistry, pharmaceutical chemistry and computational chemistry》 |2014年第1期|共6页
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Shradha P; Prateek P; Jagdamba Singh;
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机译：1,2,4-三唑苯胺衍生物和杀真菌活性的合成

Synthesis, characterization and fungicidal activity of N-(5-oxo-3,7-diaryl-6,7-dihydro-5H-thiazolo [3,2,a] pyrimidin-6-yl) benzamide derivatives

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