Synthesis and evaluation of new phenylamino-thiadiazolo-oxadiazolo-1, 3-benzoxazoles for their antifungal and anti-inflammatory activity

L. Srikanth; Usha Naik; Ramesh Jadhav; N.Raghun; J. Venkateshwar Rao; K. Raj manohar

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Synthesis and evaluation of new phenylamino-thiadiazolo-oxadiazolo-1, 3-benzoxazoles for their antifungal and anti-inflammatory activity

机译：新型苯氨基噻二唑-恶二唑-1、3-苯并恶唑的合成及其抗真菌和抗炎活性的评价

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In view of various biological activities of benzoxazoles, thiadiazoles and oxadiazole derivatives, it was our interest to prepare benzoxazole derivatives involving 1,3,4-thiadiazole and 1,3,4- oxadiazole nucleus and evaluate them for antifungal and anti-inflammatory activity using carrageenan induced rat paw edema model. The structures of all the synthesized compounds were characterized by IR, 1H-NMR and MASS spectral data. All the synthesized compounds were screened for antifungal and anti-inflammatory activity. Among all the active compounds thiadiazole and oxadiazole derivatives showed good activity.

机译：鉴于苯并恶唑，噻二唑和恶二唑衍生物的各种生物活性，我们的兴趣是制备涉及1,3,4-噻二唑和1,3,4-恶二唑核的苯并恶唑衍生物，并使用它们评估其抗真菌和抗炎活性。角叉菜胶诱导的大鼠爪水肿模型。通过IR，1 H-NMR和MASS光谱数据表征所有合成的化合物的结构。筛选所有合成的化合物的抗真菌和抗炎活性。在所有活性化合物中，噻二唑和恶二唑衍生物均显示出良好的活性。

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《Der Pharma Chemica: journal for medicinal chemistry, pharmaceutical chemistry and computational chemistry》 |2010年第4期|共13页
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L. Srikanth; Usha Naik; Ramesh Jadhav; N.Raghun; J. Venkateshwar Rao; K. Raj manohar;
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Synthesis and evaluation of new phenylamino-thiadiazolo-oxadiazolo-1, 3-benzoxazoles for their antifungal and anti-inflammatory activity

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