Some new 3,4-disubstituted pyrroles and pyrazoles w ere prepared from the synthetic intermediate (E)-1- (4-(m- chlorobenzyloxy)-3-methoxyphenyl)-3-(4-aryl)prop-2- en-1-one on treatment with tosylmethyl isocyanide a nd diazomethane. All the target compounds were evaluat ed for antimicrobial activity. The chloro substitut ed pyrroles and pyrazoles ( 5c , 7c ) exhibited pronounced antimicrobial activity parti cularly against S. aureus and P. chrysogenum.
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