Design and Synthesis of Classical Dihydropyrimidone Derivatives from Azosalicyaldehydes

Sushil R Mathapati; Mantosh B Swami; Arvind H Jadhav; Namdev V Ghule; Jairaj K Dawle

首页> 外文期刊>Der Pharma Chemica: journal for medicinal chemistry, pharmaceutical chemistry and computational chemistry >Design and Synthesis of Classical Dihydropyrimidone Derivatives from Azosalicyaldehydes

【24h】

Design and Synthesis of Classical Dihydropyrimidone Derivatives from Azosalicyaldehydes

机译：偶氮二醛经典二氢嘧啶酮衍生物的设计与合成

获取原文

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

A series of classical Dihydropyrimidone (DHP) derivatives were synthesize from o-hydroxy aldehydes. Azosalicyaldehydes were prepared from various substituted anilines with salicylaldehyde by the reported process. These Azosalicyaldehydes were reacts with ethylacetoacetate and urea in presence of ZnCl2 catalyst under 70-80°C temperature gives reported DHP products rather than oxygen bridged tricyclic product. The present method is founds eco-friendly, highly efficient, and clean method for the selective synthesis of DHP derivatives.

机译：由邻羟基醛合成了一系列经典的二氢嘧啶酮（DHP）衍生物。通过报道的方法，用水杨醛由各种取代的苯胺制备了氮杂醛。在ZnCl2催化剂的存在下，在70-80°C的温度下，将这些氮杂乙醛与乙酰乙酸乙酯和尿素反应，得到了报道的DHP产物，而不是氧桥连的三环产物。本发明方法发现了用于DHP衍生物的选择性合成的生态友好，高效且清洁的方法。

著录项

来源
《Der Pharma Chemica: journal for medicinal chemistry, pharmaceutical chemistry and computational chemistry》 |2017年第6期|共5页
作者
Sushil R Mathapati; Mantosh B Swami; Arvind H Jadhav; Namdev V Ghule; Jairaj K Dawle;
展开▼
作者单位

展开▼
收录信息
原文格式 PDF
正文语种
中图分类化学;
关键词

相似文献

外文文献
中文文献
专利

1. Synthesis, characterization and evaluation of cytotoxic and antioxidant activities of dihydropyrimidone substituted pyrrole derivatives [J] . Khalilpour Asieh, Asghari Sakineh Medicinal chemistry research: an international journal for rapid communications on design and mechanisms of action of biologically active agents . 2018,第1期

机译：二氢嘧啶取代吡咯衍生物的细胞毒性和抗氧化活性的合成，表征及评价
2. Free-ZnO nanoparticles: a mild, efficient and reusable catalyst for the one-pot multicomponent synthesis of tetrahydrobenzo[b]pyran and dihydropyrimidone derivatives [J] . Subhash Banerjee, Arijit Saha New Journal of Chemistry . 2013,第12期

机译：游离ZnO纳米颗粒：一种温和，有效且可重复使用的催化剂，用于一锅多组分合成四氢苯并[b]吡喃和二氢嘧啶酮衍生物
3. Design, synthesis and antimicrobial evaluation of dihydropyrimidone based organic-inorganic nano-hybrids [J] . Raj Tilak, Billing Beant Kaur, Kaur Navneet, RSC Advances . 2015,第58期

机译：基于二氢嘧啶酮的有机-无机纳米杂化物的设计，合成及抗菌性能评价
4. DESIGN AND SYNTHESIS OF SOME NOVEL ERLOTINIB DERIVATIVES AS POTENTIAL EGFR KINASE INHIBITORS [C] . V.Ajeesh, S.Shubham, M.Ruchi Conference on Drug Design and Discovery Technologies . 2020

机译：一些新型欧尔替尼衍生物的设计与合成潜在EGFR激酶抑制剂
5. Part One. Synthesis of optically active tryptophan derivatives with potential activity as indoleamine 2,3-dioxygenase inhibitors: An approach via asymmetric catalytic hydrogenation. Part Two. Design, synthesis and pharmacology of selective ligands for alpha1-containing GABA(A)/benzodiazepine receptor subtypes: SAR studies of beta-carbolines at positions -3 and -6 and their corresponding bivalent ligands. Part Three. First enantiospecific total synthesis of the important biogenetic intermediates, (+)-polyneuridine and (+)-polyneuridine aldehyde, as well as 16-epi-vellosimine and macusine A. [D] . Yin, Wenyuan. 2007

机译：第一部分。具有吲哚胺2,3-二加氧酶抑制剂潜在活性的旋光色氨酸衍生物的合成：一种通过不对称催化氢化的方法。第二部分。含α1的GABA（A）/苯并二氮杂receptor受体亚型的选择性配体的设计，合成和药理作用：位于-3和-6位的β-咔啉及其相应的二价配体的SAR研究。第三部分。重要生物遗传中间体，（+）-聚神经氨酸和（+）-聚神经氨酸醛，以及16-表-维西辛和Macusine A的首次对映体全合成。
6. Innovative Three-Step Microwave-Promoted Synthesis of N-Propargyltetrahydroquinoline and 123-Triazole Derivatives as a Potential Factor Xa (FXa) Inhibitors: Drug Design Synthesis and Biological Evaluation [O] . Fabián Santana-Romo, Carlos F. Lagos, Yorley Duarte, 2020

机译：创新的三步微波促进合成N-炔丙基四氢喹啉和123-三唑衍生物作为潜在因子Xa（FXa）抑制剂：药物设计合成和生物学评估
7. Design, synthesis and preliminary structure–activity relationship investigation of nitrogen-containing chalcone derivatives as acetylcholinesterase and butyrylcholinesterase inhibitors: a further study based on Flavokawain B Mannich base derivatives [O] . Haoran Liu, Haoqun Fan, Xiaohui Gao, 2015

机译：含氮的胆酮衍生物作为乙酰胆碱酯酶和丁二醇酸酶抑制剂的设计，合成和初步结构 - 活性关系研究：基于Flavokawain B Mannich基础衍生物的进一步研究
8. Multivariable Feedback Design: Concepts for a Classical/Modern Synthesis. [R] . Doyle, J. C., Stein, G. 1980

机译：多变量反馈设计：经典/现代综合的概念。

Design and Synthesis of Classical Dihydropyrimidone Derivatives from Azosalicyaldehydes

摘要

著录项

相似文献

相关主题

期刊订阅