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Utility and Safety of ERCP in the Elderly: A Comparative Study in Iran

机译:老年人ERCP的实用性和安全性:伊朗的比较研究

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Background. The present study sought and compared the utility and safety of endoscopic retrograde cholangiopancreatography (ERCP) in the elderly and younger people in a great sample of Iranian population.Methods. Our study involved 780 patients undergoing diagnostic and therapeutic ERCP at the Taleghani hospital in Tehran between 2010 and 2011; among them, 558 patients were less than 70 years old and others were 70 years old or older. The patients were prospectively identified and data including clinical and biochemical features, ERCP procedures, ERCP diagnosis, and ERCP complications were gathered on them prospectively.Results. Clinical manifestations were comparable in young and older groups except for hepatosplenomegaly and constipation that were more prevalent in the elderly. Laboratory findings were similar in both groups other than mean levels of alkaline phosphatase, hemoglobin and albumin levels, which were higher in the elderly group. Selective biliary cannulation was technically more successful in the younger than in others (89.0% versus 81.8%). Common bile duct stone was the most frequent diagnosis in both young and older groups (36.6% and 45.9%, resp.), whereas ERCP was reported to be normal in 13.4% of the younger and 5.0% of the elderly patients. Post-ERCP complications were observed in 4.8% of patients aged less than 70 years in comparison with 2.3% of patients aged over 70 years. The most frequent complication was pancreatitis that was significantly more developed in young than older patients (3.6% versus 1.5%; OR: 8.216,P=0.015).Conclusion. Diagnostic ERCP is safe and well tolerated in the elderly and even associated with significantly less risk than the younger.
机译:背景。本研究寻求并比较了大量伊朗人群中内窥镜逆行胰胆管造影(ERCP)在老年人和年轻人中的实用性和安全性。我们的研究涉及2010年至2011年间在德黑兰Taleghani医院接受ERCP诊断和治疗的780名患者。其中558例患者年龄小于70岁,其他患者年龄大于或等于70岁。对患者进行前瞻性鉴定,并对其前瞻性收集包括临床和生化特征,ERCP程序,ERCP诊断和ERCP并发症在内的数据。除肝脾肿大和便秘在老年人中更普遍外,青年组和老年组的临床表现相当。除碱性磷酸酶,血红蛋白和白蛋白的平均水平外,两组的实验室检查结果相似,老年人组较高。选择性胆管插管在年轻人中比其他人更成功(89.0%比81.8%)。在年轻和老年组中,胆总管结石是最常见的诊断方法(分别为36.6%和45.9%),而据报告,ERCP在年轻患者中占13.4%,在老年患者中占5.0%。年龄小于70岁的患者中有4.8%发生了ERCP后并发症,而年龄大于70岁的患者中有2.3%发生了并发症。最常见的并发症是胰腺炎,其在年轻患者中的发生率明显高于老年患者(3.6%对1.5%; OR:8.216,P = 0.015)。诊断性ERCP在老年人中是安全且耐受性良好的,甚至与年轻人相比风险要低得多。

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