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首页> 外文期刊>Diagnostic pathology >Expression of pRb and p16INK4 in human thymic epithelial tumors in relation to the presence of human polyomavirus 7
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Expression of pRb and p16INK4 in human thymic epithelial tumors in relation to the presence of human polyomavirus 7

机译：pRb和p16INK4在人胸腺上皮肿瘤中的表达与人多瘤病毒7的存在有关

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Background We have recently reported the presence of the Human polyomavirus 7 (HPyV7) in human thymic epithelial tumors as assessed by diverse molecular techniques. Here we report on the co-expression of p16, retinoblastoma protein (pRb) and phosphorylated retinoblastoma protein (phospho-Rb) in human thymic epithelial tumors in relation to HPyV7. Methods PRB, phospho-RB and p16 expression was assessed by immuno-histochemistry in 37 thymomas and 2 thymic carcinomas. 17 thymomas (46 %) and 1 thymic carcinoma (50 %) were recently tested positive for HPyV7. In addition, 20 follicular hyperplasias were tested. Results Expression of pRb was observed in 35 thymomas (94.6 %), in 16 thymomas (43.2 %) the expression was strong. Phospho-Rb was observed in 31 thymomas (83.8 %). 19 thymomas (51.4 %) showed immunoreactivity for p16 of which 8 thymomas revealed very strong p16 expression. No p16 expression was detected in thymic carcinomas. In addition, no significant correlation between the presence of HPyV7 and pRb-, phospho-Rb- and p16-expression could be established. No correlation between pRb, phospho-Rb, p16 and WHO staging, Masaoka-Koga staging or the presence of MG was found. All 20 follicular hyperplasias showed expression of pRb and less expression of phospho-Rb. Conclusions Although polyomaviruses have been shown to interact with cell cycle proteins no correlation between the presence of HPyV7 and the expression of pRb, phospho-Rb and p16 in human thymic epithelial tumors was observed. In as much HPyV7 contributes to human thymomagenesis remains to be established. Our data indicate pRb, phospho-Rb and p16 expression are rather unlikely to be involved in HPyV7 related thymomagenesis.
机译：背景技术我们最近报道了通过多种分子技术评估的人胸腺上皮肿瘤中存在人类多瘤病毒7（HPyV7）。在这里，我们报告有关人胸腺上皮肿瘤中与HPyV7相关的p16，视网膜母细胞瘤蛋白（pRb）和磷酸化视网膜母细胞瘤蛋白（phospho-Rb）的共表达。方法采用免疫组织化学方法检测37例胸腺瘤和2例胸腺癌中PRB，磷酸化RB和p16的表达。最近检测出17例胸腺瘤（46％）和1例胸腺癌（50％）对HPyV7呈阳性。另外，测试了20个滤泡增生。结果35例胸腺瘤中观察到pRb表达（94.6％），16例胸腺瘤（43.2％）中pRb表达强。在31个胸腺瘤中观察到了磷酸Rb（83.8％）。 19个胸腺瘤（51.4％）显示出对p16的免疫反应性，其中8个胸腺瘤显示出很强的p16表达。在胸腺癌中未检测到p16表达。另外，在HPyV7的存在与pRb-，磷酸-Rb-和p16-表达之间没有明显的相关性。在pRb，phospho-Rb，p16与WHO分期，Masaoka-Koga分期或MG存在之间未发现相关性。全部20个滤泡增生均显示pRb的表达而磷酸Rb的表达较少。结论尽管已证明多瘤病毒与细胞周期蛋白相互作用，但在人胸腺上皮肿瘤中HPyV7的存在与pRb，磷酸化Rb和p16的表达之间没有相关性。 HPyV7对人类胸腺发生的贡献有待确定。我们的数据表明pRb，磷酸Rb和p16表达不太可能与HPyV7相关的胸腺瘤发生有关。

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