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首页> 外文期刊>Drug Target Insights >Antibodies Against Gonadotropin-Releasing Hormone in Patients with Posterior Laryngitis
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Antibodies Against Gonadotropin-Releasing Hormone in Patients with Posterior Laryngitis

机译：后喉炎患者抗促性腺激素释放激素的抗体

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Patients with functional gastrointestinal disorders express antibodies against gonadotropin-releasing hormone (GnRH) in serum. One common cause of posterior laryngitis (PL) is extra-esophageal reflux, but a functional etiology has also been suggested. The aim of this study was to scrutinize patients with PL with regard to the presence of GnRH antibodies and to examine the association between antibodies and symptoms and reflux. Consecutive PL patients were included after examination. Serum was analyzed for the presence of antibodies using an enzyme-linked immunosorbent assay (ELISA) method and expressed as relative units (RU). Two age- and gender-matched healthy subjects per case served as controls. The prevalence of IgM GnRH antibodies in patients was 35% compared with 28% in controls (P = 0.06), with higher levels in patients (0.8 (0.3–2.2) RU) than in controls (0.2 (0.1–0.6) RU) (P = 0.007). The corresponding IgG antibody prevalences were 43% and 4%, respectively (P = 0.001), with no difference in levels (P = 0.70). There was no association between antibodies and clinical findings.
机译：患有功能性胃肠道疾病的患者在血清中表达针对促性腺激素释放激素（GnRH）的抗体。喉后炎（PL）的一个常见原因是食管外反流，但也有人提出了功能病因。这项研究的目的是就GnRH抗体的存在对PL患者进行详细检查，并检查抗体与症状和反流之间的关联。检查后包括连续性PL患者。使用酶联免疫吸附测定（ELISA）方法分析血清中抗体的存在，并表示为相对单位（RU）。每例两个年龄和性别匹配的健康受试者作为对照。患者中IgM GnRH抗体的患病率为35％，而对照组中为28％（P = 0.06），患者水平（0.8（0.3-2.2）RU）比对照组（0.2（0.1-0.6）RU）高（ P = 0.007）。相应的IgG抗体患病率分别为43％和4％（P = 0.001），水平没有差异（P = 0.70）。抗体与临床发现之间没有关联。

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