• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Drug Target Insights >Electrocardiographic Findings in Acutely and Chronically T. cruzi-infected Mice Treated by a Phenyl-Substituted Analogue of Furamidine DB569
【24h】

Electrocardiographic Findings in Acutely and Chronically T. cruzi-infected Mice Treated by a Phenyl-Substituted Analogue of Furamidine DB569

机译：呋喃啶DB569的苯基取代类似物治疗急性和慢性克鲁氏锥虫感染小鼠的心电图结果

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Aromatic diamidines have been successfully used to combat a wide range of parasites that cause important human infections. Recently we reported that a N-phenyl-substituted analogue of furamidine (DB569) exerts a micromolar trypanocidal activity against Trypanosoma cruzi in vitro. Since DB569 also reduces the cardiac parasitism and increases the survival rates of T. cruzi-infected mice, our present aim was to analyze the potential protection of DB569 in the development of altered cardiac electrical conduction system during acute and chronic T. cruzi infection. In our experimental model of acute infection (Swiss mice inoculated with Y strain of T. cruzi), the prevailing disorder observed in electrocardiogram (ECG) analyses was sinus bradycardia. This ECG alteration was reverted in acutely infected mice treated with DB569. Interestingly, the DB569 treatment reduced significantly the numbers of CD8+ T cells in the cardiac infiltration. In addition, the noticed protection of DB569 in the ECG findings of acutely-infected animals was further extended to the chronic infection. Our data suggest that the reversion to and further maintenance of normal ECG profi le in the DB569-treated infected animals may be associated with the reduced cardiac CD8+ lymphocyte infiltration and parasitism that might be ultimately contributing to their increased survival rates.
机译：芳香族二am已被成功用于对抗引起人类重要感染的多种寄生虫。最近，我们报道了呋喃啶的N-苯基取代类似物（DB569）在体外对克氏锥虫具有微摩尔的锥虫杀虫活性。由于DB569还可以减少心脏寄生性疾病并提高感染克氏锥虫的小鼠的存活率，因此我们目前的目标是分析DB569在急性和慢性克氏锥虫感染期间心脏电传导系统改变中的潜在保护作用。在我们的急性感染实验模型中（瑞士小鼠接种了克鲁维耶氏酵母的Y株），在心电图（ECG）分析中观察到的主要疾病是窦性心动过缓。在用DB569治疗的急性感染小鼠中，这种ECG改变得以恢复。有趣的是，DB569处理可显着减少心脏浸润中CD8 + T细胞的数量。此外，在急性感染动物的心电图中，DB569的显着保护作用进一步扩展到了慢性感染。我们的数据表明，经DB569治疗的被感染动物体内正常心电图谱的恢复和进一步维持可能与减少的心脏CD8 +淋巴细胞浸润和寄生虫有关，这可能最终有助于提高其存活率。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号