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首页> 外文期刊>The Journal of Antimicrobial Chemotherapy >Trypanocidal activity of the phenyl-substituted analogue of furamidine DB569 against Trypanosoma cruzi infection in vivo.
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Trypanocidal activity of the phenyl-substituted analogue of furamidine DB569 against Trypanosoma cruzi infection in vivo.

机译：呋喃啶DB569的苯基取代类似物在体内对克氏锥虫感染的锥虫杀虫活性。

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OBJECTIVES: Aromatic diamidines have been successfully used to combat a wide range of parasites that cause important human infections. One such compound is furamidine (DB75) and we recently reported that one of its analogues, an N-phenyl analogue (DB569), exhibits higher trypanocidal dose and time-dependent effects against different forms of Trypanosoma cruzi as compared with DB75. Our present aim was to investigate the efficacy of DB569 in a T. cruzi mouse model. METHODS: The trypanocidal activity of the compound was evaluated by clinical, parasitological, histopathological and biochemical investigations. RESULTS: Treatment with DB569 significantly reduced cardiac parasitism, partially increased the survival rates of mice and lowered the levels of alanine aminotransferase and creatinine indicating a protective role against renal and hepatic lesions caused by the parasite infection. CONCLUSIONS: Altogether, the data support the potential effect of this class of compounds against T. cruzi and motivate the screening of new diamidines for efficacy against Chagas' disease.
机译：目标：芳香族二am已被成功用于对抗引起重要人类感染的多种寄生虫。一种这样的化合物是呋喃idine啶（DB75），我们最近报道说，与DB75相比，其类似物之一，N-苯基类似物（DB569）对不同形式的克氏锥虫表现出更高的锥虫杀灭剂量和时间依赖性。我们目前的目的是研究DB569在T. cruzi小鼠模型中的功效。方法：通过临床，寄生虫学，组织病理学和生化研究评估了该化合物的杀锥虫活性。结果：DB569治疗显着降低了心脏寄生虫病，部分提高了小鼠的存活率，并降低了丙氨酸氨基转移酶和肌酐的水平，表明对由寄生虫感染引起的肾脏和肝脏损害具有保护作用。结论：总体而言，数据支持这类化合物对克氏锥虫的潜在作用，并激发了筛选新的二am抗查加斯氏病的功效。

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