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首页> 外文期刊>Drug Target Insights >Study of Alkylglycerol Containing Shark Liver Oil: a Physico Chemical Support for Biological Effect?
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Study of Alkylglycerol Containing Shark Liver Oil: a Physico Chemical Support for Biological Effect?

机译：含鲨鱼肝油的烷基甘油的研究：生物化学的物理化学支持物吗？

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Shark liver oil (SLO), is used in natural medicine as immunity stimulant, cardiovascular protector and anti ageing reagent. These properties were related with the high amounts of alkylglycerols (22%) obtained from Greenland shark liver. After a control of the mean SLO composition by NMR and MS, surface and membrane interactions and antioxidant properties were investigated using NMR, ESR and ST measurements and the in vitro consequences on erythrocytes and cells were studied. An estimation of the composition of this extract was performed. Moreover, SLO was found not haemolytic (A concentration inducing 50% haemolysis, HC50 could not be reached) and superficial tension measurements revealed slight tension active properties. The 31P and 2H –NMR and ESR studies of phospholipid dispersions (dimyristoyl phosphatidyl cholin, DMPC) in the presence of SLO showed a significant increase in membrane fluidity at low temperature (below phase transition temperature) predominantly observed at the surface level. The anti oxidant activity was also confirmed, similar as that observed for vitamin E.
机译：鲨鱼肝油（SLO）在天然药物中用作免疫刺激剂，心血管保护剂和抗衰老剂。这些性质与从格陵兰鲨鱼肝中获得的大量烷基甘油（22％）有关。在通过NMR和MS控制平均SLO组成后，使用NMR，ESR和ST测量研究了表面和膜的相互作用以及抗氧化性能，并研究了其对红细胞和细胞的体外影响。估计该提取物的组成。此外，发现SLO不能溶血（浓度引起50％溶血，无法达到HC50），表面张力测量显示轻微的张力活性。在SLO存在下的磷脂分散体（二肉豆蔻酰磷脂酰胆碱，DMPC）的31P和2H -NMR和ESR研究表明，在低温（低于相变温度）时，主要在表面水平观察到了膜流动性的显着增加。还证实了抗氧化活性，类似于对维生素E观察到的抗氧化活性。

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