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首页> 外文期刊>Drug Target Insights >Evidence of a Novel Gene from Aeromonas hydrophila Encoding a Putative Siderophore Receptor Involved in Bacterial Growth and Survival
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Evidence of a Novel Gene from Aeromonas hydrophila Encoding a Putative Siderophore Receptor Involved in Bacterial Growth and Survival

机译：嗜水气单胞菌的一个新基因的编码一个假定的铁载体受体参与细菌生长和存活的证据。

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摘要

The pathogenic bacterium Aeromonas hydrophila has been shown to exclusively utilize a ligand exchange mechanism for siderophore-mediated iron uptake, with a single nonspecific siderophore receptor facilitating iron exchange. However, the genes involved in this process, including the gene encoding the nonspecific receptor, are unknown. Here we identify and characterize a novel gene, nsr1, from A. hydrophila that encodes a putative protein with high homology and significant predicted structural similarities to the FhuA protein and other known ferric-siderophore receptors. This protein appears to localize on the cell membrane and is likely to be the receptor involved in the ligand exchange siderophore-mediated iron uptake mechanism of A. hydrophila. It is expected that this information may lead to the development of new antibiotics targeting either nsr1 or its gene product for use in controlling A. hydrophila infection.
机译：致病性细菌嗜水气单胞菌已被证明仅利用配体交换机制用于铁载体介导的铁吸收，而单个非特异性铁载体受体则促进铁交换。但是，涉及该过程的基因，包括编码非特异性受体的基因，是未知的。在这里，我们从嗜水气单胞菌中鉴定并鉴定了一个新基因nsr1，该基因编码一种推定的蛋白，与FhuA蛋白和其他已知的铁-铁载体具有高度的同源性和显着的预测结构相似性。该蛋白似乎位于细胞膜上，并且很可能是参与亲水性链球菌的配体交换铁载体介导的铁吸收机制的受体。预计该信息可能会导致开发针对nsr1或其基因产物的新型抗生素，以用于控制亲水性链球菌感染。

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