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首页> 外文期刊>Journal of atherosclerosis and thrombosis. >Lipid Parameters are Independently Associated with Cardio–Ankle Vascular Index (CAVI) in Healthy Japanese Subjects
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Lipid Parameters are Independently Associated with Cardio–Ankle Vascular Index (CAVI) in Healthy Japanese Subjects

机译：在健康的日本受试者中，脂质参数与心踝血管指数（CAVI）独立相关

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Aim : To investigate the associations of conventional lipid parameters with arterial stiffness assessed by cardio–ankle vascular index (CAVI). Methods : A retrospective cross-sectional study was conducted in 23,257 healthy Japanese subjects (12,729 men and 10,528 women, aged 47.1±12.5 years, body mass index (BMI) 22.9±3.4 kg/m2) who underwent health screening between 2004 and 2006 in Japan. Results : Male subjects had significantly higher BMI, CAVI and triglycerides (TG), and lower high-density lipoprotein cholesterol (HDL-C) compared to female subjects. After adjusting for confounders, including gender, age, systolic blood pressure and BMI identified by multiple regression analysis, adjusted CAVI was lower in normolipidemic than in dyslipidemic subjects. Among dyslipidemic subjects, those with hypertriglyceridemia had higher adjusted CAVI. A trend test detected linear relations between adjusted CAVI and all the conventional lipid parameters throughout the entire range of serum levels. After adjusting for confounders, logistic regression models showed that all lipid parameters contributed independently to high CAVI (≥90th percentile). Receiver–operating–characteristic analysis determined reliable cut-off values of 93 mg/dl for TG (area under the curve, AUC= 0.735), 114 mg/dl for low-density lipoprotein cholesterol (AUC=0.614) and 63 mg/dl for HDL-C (AUC=0.728) in predicting high CAVI. These cut-off values were confirmed to independently predict high CAVI in a bivariate logistic regression model. Conclusion : The present study demonstrated independent contribution of conventional lipid parameters to CAVI, indicating a possible association of lipid parameters with early vascular damage.
机译：目的：探讨常规脂质参数与通过心踝血管指数（CAVI）评估的动脉僵硬度之间的关系。方法：对23257名健康的日本受试者（男性12729例和女性10528例，年龄47.1±12.5岁，体重指数（BMI）22.9±3.4 kg / m 2 ）进行了回顾性横断面研究。在2004年至2006年间对日本进行了健康检查。结果：与女性受试者相比，男性受试者的BMI，CAVI和甘油三酸酯（TG）显着较高，而高密度脂蛋白胆固醇（HDL-C）较低。在通过多元回归分析对包括性别，年龄，收缩压和BMI在内的混杂因素进行调整后，正常血脂病患者的调整CAVI低于血脂异常患者。在血脂异常受试者中，高甘油三酯血症患者的CAVI调整值较高。趋势测试检测了在整个血清水平范围内，调整后的CAVI与所有常规脂质参数之间的线性关系。调整混杂因素后，逻辑回归模型显示所有脂质参数均独立导致高CAVI（≥90％）。接收者-操作者-特征分析确定了TG的可靠临界值（曲线下面积，AUC = 0.735）为93 mg / dl，低密度脂蛋白胆固醇（AUC = 0.614）为63 mg / dl，可靠的临界值为63 mg / dl HDL-C（AUC = 0.728）预测高CAVI。在双变量逻辑回归模型中，确认了这些临界值可独立预测高CAVI。结论：本研究表明常规脂质参数对CAVI的独立贡献，表明脂质参数可能与早期血管损伤有关。

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