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首页> 外文期刊>Journal of Behavioral and Brain Science >Basolateral Amygdala Inactivation Reduces Sexual Motivation in Male Rats during Performance of a T-Maze Task with a Sexual Reward
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Basolateral Amygdala Inactivation Reduces Sexual Motivation in Male Rats during Performance of a T-Maze Task with a Sexual Reward

机译：基底外侧杏仁核失活降低了雄性大鼠性行为的T迷宫任务的执行过程中的性动机。

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This study was aimed to determine the effect of amygdaline inactivation on the sexual motivation of male rats during a T-maze task with a sexual reward. Subjects were chronically implanted with two stainless-steel cannulae that enabled the infusion of tetrodotoxin, a sodium channel blocker, into the left and right basolateral amygdala (BLA). Animals were divided into 3 groups: saline (SS); TTX1 (tetrodotoxin at 2.5 ng); and TTX2 (tetrodotoxin at 5.0 ng). To induce a sexually-motivated state, all male rats were allowed to have an intromission with a receptive female before performing the T-maze task, after which their sexual motivation was evaluated during seven trials in which a receptive female was placed in one goal-box of the T-maze, and a non-receptive one in the other. Subjects were allowed an intromission as a sexual reward whenever they reached the goal-box containing the receptive female, but were returned to the start-box if they did not. At the end of the experiment, copulation until ejaculation was permitted. Both doses of TTX increased the time rats required to cross the maze stem during the final trials. In terms of sexual interaction, the high dose of TTX increased more markedly mount, intromission and ejaculation latencies and the number of mounts and intromissions. Overall, these results indicate that the BLA may play an important role in modulating sexual behavior, particularly in maintaining sexual motivation in successive trials in a T-maze task and during sexual interaction per se.
机译：这项研究的目的是确定在具有性奖励的T型迷宫任务中，扁桃体失活对雄性大鼠性动机的影响。受试者被长期植入两个不锈钢套管，该套管能够将河豚毒素（一种钠通道阻滞剂）输注到左右基底外侧杏仁核（BLA）中。将动物分为3组：生理盐水（SS）;生理盐水。 TTX1（2.5 ng河豚毒素）;和TTX2（5.0 ng河豚毒素）。为了诱发性动机状态，在执行T-迷宫任务之前，所有雄性大鼠均接受雌性雌性的激进，此后在7项试验中评估了它们的性动机，其中将雌性雌性置于一个目标中，盒装的T型迷宫，另一个不接受。每当受试者到达包含接受雌性的目标箱时，都可以将其引入性生活作为性奖励，但如果没有进入目标箱，则将其返回起始箱。在实验结束时，允许交配直至射精。在最终试验期间，两种剂量的TTX都增加了大鼠穿越迷宫茎所需的时间。在性交方面，高剂量的TTX增加了坐骑，内射和射精的潜伏期以及坐骑和内射的次数。总体而言，这些结果表明，BLA可能在调节性行为方面起着重要作用，尤其是在T型迷宫任务的后续试验中以及在性交本身本身方面，在保持性动机方面。

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