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首页> 外文期刊>Journal of Behavioral and Brain Science >Repeated Physical Training and Environmental Enrichment Induce Neurogenesis and Synaptogenesis Following Neuronal Injury in an Inducible Mouse Model
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Repeated Physical Training and Environmental Enrichment Induce Neurogenesis and Synaptogenesis Following Neuronal Injury in an Inducible Mouse Model

机译：反复的体育锻炼和环境丰富诱导神经元损伤诱导小鼠模型中的神经发生和突触发生。

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Neuronal loss as a consequence of brain injury, stroke and neurodegenerative disorders causes functional impairments ranging from cognitive impairments to physical disabilities. Extensive rehabilitation and trainning may lead to neuroprotection and promote functional recovery, although little is known about the molecular and cellular mechanisms driving this event. To investigate the underlying mechanisms and levels of functional recovery elicited by repeated physical training or environmental enrichment, we generated an inducible mouse model of selective CA1 hippocampal neuronal loss. Following the CA1 neuronal injury, mice underwent one of the above mentioned conditions for 3 months. Exposure to either of these stimuli promoted functional cognitive recovery, which was associated with increased neurogenesis in the subgranular zone of dentate gyrus and enhanced synaptogenesis in the CA1 subfield. Notably, a significant correlation was found between the functional recovery and increased synaptogenesis among survived CA1 neurons. Collectively, these results support the utilization of cognitive and physical stimulation as approaches to promote recovery after neuronal loss and demonstrate the potential of this novel mouse model for the development of therapeutic strategies for various neurological disorders associated with focal neuronal loss.
机译：由脑损伤，中风和神经退行性疾病引起的神经元丧失会导致功能障碍，从认知障碍到身体残疾。广泛的康复和训练可能导致神经保护并促进功能恢复，尽管对驱动此事件的分子和细胞机制知之甚少。为了研究通过反复的体育锻炼或环境丰富化引起的功能恢复的潜在机制和水平，我们生成了选择性CA1海马神经元丢失的诱导型小鼠模型。在CA1神经元损伤后，小鼠经历上述条件之一，持续3个月。暴露于这些刺激中的任何一个都促进了功能性认知恢复，这与齿状回的亚颗粒区神经发生增加和CA1子域的突触形成增加有关。值得注意的是，发现存活的CA1神经元之间的功能恢复与突触形成之间存在显着相关性。总的来说，这些结果支持认知和物理刺激的利用，作为促进神经元丢失后恢复的方法，并证明了这种新型小鼠模型对于发展与局灶性神经元丢失相关的各种神经疾病的治疗策略的潜力。

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