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首页> 外文期刊>Journal of Cancer Research and Therapeutics >Urine PCA3 mRNA level in diagnostic of prostate cancer
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Urine PCA3 mRNA level in diagnostic of prostate cancer

机译：尿中PCA3 mRNA水平在前列腺癌诊断中的作用

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Objective: The objective of this study is to evaluate the diagnostic effects of urine PCA3 mRNA level in patients with prostate cancer (PC). Methods: Twenty four patients with pathologically confirmed PC, 40 patients with benign prostatic hyperplasia (BPH), and 13 patients with urolithiasis were recruited in this study. The urine level of PCA3 mRNA was determined with real-time polymerase chain reaction and compared among the three groups. With the reference parameter of urine PCA3 mRNA, the diagnostic sensitivity, specificity, and area under the receiver operating characteristic curve (AUC) were calculated. Results: The mRNA level in urine of PC, BPH and urolithiasis were 60.2 ± 32.2, 17.1 ± 12.9, and 6.2 ± 3.1, respectively, indicating that mRNA level in PC was significantly higher than that of in other two groups (P Conclusion: The urine PCA3 mRNA could be a biomarker for diagnosing patients with PC.
机译：目的：本研究的目的是评估尿液PCA3 mRNA水平对前列腺癌（PC）患者的诊断作用。方法：本研究招募了24例经病理证实的PC的患者，40例良性前列腺增生（BPH）的患者和13例尿路结石的患者。用实时聚合酶链反应测定尿中PCA3 mRNA的水平，并在三组之间进行比较。使用尿液PCA3 mRNA的参考参数，计算诊断灵敏度，特异性和受体工作特征曲线（AUC）下的面积。结果：PC，BPH和尿路结石的尿中mRNA水平分别为60.2±32.2、17.1±12.9和6.2±3.1，表明PC中的mRNA水平显着高于其他两组（P结论：尿中PCA3 mRNA可能是诊断PC患者的生物标志物。

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